Extra-esophageal manifestations of gastroesophageal reflux disease: Controversies between epidemiology and clicnic

Saber, H. and Ghanei, M. (2012) Extra-esophageal manifestations of gastroesophageal reflux disease: Controversies between epidemiology and clicnic. Open Respiratory Medicine Journal, 6 (1). pp. 121-126.

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Gastroesophageal reflux disease (GERD) is widely associated with asthma, chronic cough, and laryngitis. Many studies have focused on acidic reflux; however, acid is just one of many factors that can cause pulmonary injury. The discrepancy between the high frequency of GERD in asthmatic patients and the ineffective reflux therapy outcomes in these patients suggests that GERD may cause injury through other mechanisms, such as pepsinogen, pepsin, bile salts, or other components of reflux materials, instead of the acid. Research using appropriate and innovative methodologies to investigate these potential inflammatory agents in patients with GERD is required to determine the underlying factors associated with pulmonary disorders in these patients. © Ansari et al.

Item Type: Article
Additional Information: Cited By :7 Export Date: 16 February 2020 Correspondence Address: Ghanei, M.; Research Center of Chemical Injuries, Baqiyatallah University of Medical Sciences, P.O. Box: 19945-546, Tehran, Iran; email: mghanei@hbi.ir
Uncontrolled Keywords: Asthma Cough Epidemiology Gastroesophageal reflux disease Respiratory 4 aminobutyric acid receptor stimulating agent baclofen bile salt esomeprazole lansoprazole metabotropic receptor antagonist omeprazole pepsin A pepsinogen placebo proton pump inhibitor ranitidine article chronic bronchitis chronic cough chronic obstructive lung disease cystic fibrosis diagnostic procedure disease association disease severity drug mechanism fibrosing alveolitis gastroesophageal reflux gastrointestinal surgery human laryngitis low drug dose lung injury prevalence priority journal quality of life randomized controlled trial (topic) unspecified side effect
Subjects: WI Digestive System
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 25 Apr 2020 05:44
Last Modified: 25 Apr 2020 05:44
URI: http://eprints.mums.ac.ir/id/eprint/16582

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