Preventive effect of safranal against oxidative damage in aged male rat brain

Samarghandian, S. and Azimi-Nezhad, M. and Samini, F. (2015) Preventive effect of safranal against oxidative damage in aged male rat brain. Experimental Animals, 64 (1). pp. 65-71.

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Abstract

An imbalance between production of reactive oxygen species (ROS) and its elimination by antioxidant defense system in the body has been implicated for causes of aging and neurodegenerative diseases. This study was design to assess the changes in activities of antioxidant enzymes (superoxide dismutase (SOD), glutathione-S-transferase (GST), catalase), lipid peroxidation and reduced glutathione (GSH) levels in the brain of 2, 10 and 20 month old rats, and to determine the effect of safranal on the status of selected oxidative stress indices in the 10 and 20 month old rats. The aged rats (10 and 20 months) were given intraperitoneal injections of safranal (0.5 mg/kg day) daily for one month. The results of this study demonstrated that aging caused significant increase in the level of lipid peroxidation as well decrease in the GSH level and activities of SOD and GST in the brain of aging rats. The results of this study showed that safranal ameliorated the increased lipid peroxidation level as well as decreased GSH content of the brain of 10 and 20 month old rats. In addition, safranal treatment to the 20 month old rats, which restored the SOD and GST activities. In conclusion, safranal can be effective to protect susceptible aged brain from oxidative damage by increasing antioxidant defenses. © 2015 Japanese Association for Laboratory Animal Science.

Item Type: Article
Additional Information: Cited By :30 Export Date: 16 February 2020 CODEN: JIDOA Correspondence Address: Samarghandian, S.; Department of Basic Medical Sciences, Neyshabur University of Medical SciencesIran
Uncontrolled Keywords: Aged Brain Oxidative damage Safranal antioxidant catalase glutathione glutathione transferase superoxide dismutase unclassified drug cyclohexene derivative lipid peroxide reactive oxygen metabolite terpene animal experiment Article chemical analysis controlled study enzyme activity enzyme assay lipid peroxidation male nonhuman oxidative stress protein analysis protein expression rat aging animal drug effects intraperitoneal drug administration metabolism Neurodegenerative Diseases pathology Wistar rat Rattus Animals Antioxidants Cyclohexenes Injections, Intraperitoneal Lipid Peroxides Rats, Wistar Reactive Oxygen Species Terpenes
Subjects: WL Nervous system
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 25 Apr 2020 05:57
Last Modified: 25 Apr 2020 05:57
URI: http://eprints.mums.ac.ir/id/eprint/16584

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