Decreased nitric oxide levels in the hippocampus may play a role in learning and memory deficits in ovariectomized rats treated by a high dose of estradiol

Sadeghian, R. and Fereidoni, M. and Soukhtanloo, M. and Azizi-Malekabadi, H. and Hosseini, M. (2012) Decreased nitric oxide levels in the hippocampus may play a role in learning and memory deficits in ovariectomized rats treated by a high dose of estradiol. Arquivos de Neuro-Psiquiatria, 70 (11). pp. 874-879.

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Abstract

The effects of a high estradiol dose on memory and on nitric oxide metabolites in hippocampal tissues were investigated. Sham-Est and OVX-Est Groups were treated with 4 mg/kg of estradiol valerate for 12 weeks. Time latency and path length were significantly higher in the Sham-Est and OVX-Est Groups than in the Sham and OVX Groups, respectively (p<0.001). The animals in the Sham-Est and OVX-Est Groups spent lower time in the target quadrant (Q1) than those of the Sham and OVX Groups during the probe trial test (p<0.05 and <0.001, respectively). Significantly lower nitric oxide metabolite levels in the hippocampi of the Sham-Est and OVX-Est Groups were observed than in the Sham and OVX ones (p<0.001). These results suggest that decreased nitric oxide levels in the hippocampus may play a role in the learning and memory deficits observed after treatment with a high dose of estradiol, although the precise underlying mechanisms remain to be elucidated.

Item Type: Article
Additional Information: Cited By :24 Export Date: 16 February 2020 CODEN: ANPIA Correspondence Address: Hosseini, M.; Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; email: hosseinim@mums.ac.ir
Uncontrolled Keywords: Estradiol Hippocampus Nitric oxide Rat amnesia animal experiment animal model animal tissue article controlled study drug megadose female latent period learning disorder maze test nonhuman ovariectomy postmenopause Analysis of Variance Animals Contraceptive Agents Dose-Response Relationship, Drug Humans Learning Disorders Maze Learning Memory Memory Disorders Random Allocation Rats Rats, Wistar
Subjects: WL Nervous system
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 04 Apr 2020 05:44
Last Modified: 04 Apr 2020 05:44
URI: http://eprints.mums.ac.ir/id/eprint/16591

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