Effect of L-carnitine supplementation on circulating C-reactive protein levels: A systematic review and meta-analysis

Sahebkar, A. (2015) Effect of L-carnitine supplementation on circulating C-reactive protein levels: A systematic review and meta-analysis. Journal of Medical Biochemistry, 34 (2). pp. 151-159.

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[14528266 - Journal of Medical Biochemistry] Effect of L-Carnitine Supplementation on Circulating C-Reactive Protein Levels_ A Systematic Review and Meta-Analysis _ Uticaj Suplementacije L-Karnitinom Na Nivoe .pdf

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Abstract

Background: C-reactive protein (CRP) has been proposed as a risk marker and risk factor of cardiovascular disease. There have been a number of clinical reports suggesting that supplementation with L-carnitine can modulate systemic inflammation and lower circulating CRP concentrations, but the results have not been consistent. Methods: A comprehensive literature search in Medline, Scopus and Cochrane Central Register of Controlled Trials was performed in December 2012 to identify clinical trials investigating the impact of oral L-carnitine supplementation on serum/plasma CRP concentration. A random effect method was used to calculate the combined effect size. Results: Six studies comprising 541 cases and 546 controls met the inclusion criteria. Meta-analysis of included trials revealed a significant reduction of circulating CRP concentrations in subjects under L-carnitine intervention compared to the control treatment. The calculated combined weighted mean reduction in CRP concentrations was -0.39 mg/L 95% CI (-0.62 - -0.16). This effect size estimate was found to be robust and remained unaffected by the removal of each single study. Conclusions: The overall findings of the present metaanalysis support the clinically relevant benefit of L-carnitine supplementation in lowering the circulating levels of CRP. © by Amirhossein Sahebkar 2015.

Item Type: Article
Additional Information: Cited By :14 Export Date: 16 February 2020 Correspondence Address: Sahebkar, A.; Biotechnology Research Center, Mashhad University of Medical SciencesIran
Uncontrolled Keywords: atherosclerosis carnitine clinical trial coronary artery disease nutrition systematic review C reactive protein Cochrane Library follow up human intervention study investigative procedures Medline meta analysis randomized controlled trial (topic) Review Scopus vitamin supplementation weight reduction
Subjects: QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 04 Apr 2020 08:17
Last Modified: 04 Apr 2020 08:17
URI: http://eprints.mums.ac.ir/id/eprint/16601

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