Chronic administration of a combination of six herbs inhibits the progression of hyperglycemia and decreases serum lipids and aspartate amino transferase activity in diabetic rats

Shafiee-Nick, R. and Ghorbani, A. and Vafaee Bagheri, F. and Rakhshandeh, H. (2012) Chronic administration of a combination of six herbs inhibits the progression of hyperglycemia and decreases serum lipids and aspartate amino transferase activity in diabetic rats. Advances in Pharmacological Sciences, 2012.

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Abstract

The effects of a polyherbal compound, containing six plants (Allium sativum, Cinnamomum zeylanicum, Nigella sativa, Punica granatum, Salvia officinalis and Teucrium polium) were tested on biochemical parameters in streptozotocin-induced diabetic rats. Streptozotocin caused an approximately 3-fold increase in fasting blood sugar level after 2 days. The diabetic control rats showed further increase in blood glucose after 30 days (384 ± 25 mg/dl in day 30 versus 280 ± 12 mg/dl in day 2, P<0.001). Administration of the compound blocked the increase of blood glucose (272 ± 7 and 269 ± 48 mg/dl at day 2 and day 30, respectively). Also, there was significant difference in the level of triglyceride (60 ± 9 versus 158 ± 37 mg/dl, P<0.01), total cholesterol (55 ± 2 versus 97 ± 11 mg/dl, P < 0.01) and aspartate amino transferase activity (75 ± 12 versus 129 ± 18 U/L, P<0.05) between treated rats and diabetic control group. In conclusion, the MSEC inhibited the progression of hyperglycemia and decreased serum lipids and hepatic enzyme activity in diabetic rats. Therefore, it has the potential to be used as a natural product for the management of diabetes. © 2012 Reza Shafiee-Nick et al.

Item Type: Article
Additional Information: Cited By :32 Export Date: 16 February 2020 Correspondence Address: Ghorbani, A.; Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran; email: ghorbania@mums.ac.ir
Uncontrolled Keywords: aspartate aminotransferase cholesterol cinnamomum zeylanicum extract garlic extract glucose lipid Nigella sativa extract plant extract pomegranate extract Salvia officinalis extract Teucrium polium extract triacylglycerol unclassified drug animal experiment animal model article black cumin cholesterol blood level Cinnamomum zeylanicum controlled study diabetes mellitus drug effect enzyme activity enzyme inactivation garlic glucose blood level glycemic control hyperglycemia lipid blood level male medicinal plant nonhuman pomegranate priority journal rat Salvia officinalis Teucrium polium triacylglycerol blood level
Subjects: QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 08 Apr 2020 04:02
Last Modified: 08 Apr 2020 04:02
URI: http://eprints.mums.ac.ir/id/eprint/16604

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