How should we manage a patient with invasive mucoromycosis who develops life-threatening reaction to amphotericin B? Report of two cases and literature review

Sheybani, F. and Naderi, H. and Sarvghad, M. and Ghabouli, M. and Arian, M. (2015) How should we manage a patient with invasive mucoromycosis who develops life-threatening reaction to amphotericin B? Report of two cases and literature review. Medical Mycology Case Reports, 8. pp. 29-31.

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Abstract

This report presents two cases of invasive rhino-orbital mucormycosis who had life-threatening reactions to amphotericin B. Both cases were treated with a combination of posaconazole-caspofungin favorably with no evidence of recurrence upon long-term follow-up. To our knowledge, this is the first report of successful treatment of invasive mucormycosis with azole-echinocandin combination. It may suggest that caspofungin exerts additional or even synergistic antimucoral effects to posaconazole. © 2015 International Society for Human and Animal Mycologyy Published by Elsevier B.V. All rights reserved.

Item Type: Article
Additional Information: Cited By :5 Export Date: 16 February 2020 Correspondence Address: Naderi, H.; Department of infectious Diseases, Mashhad University of Medical Sciences, Imam Reza Teaching HospitalIran
Uncontrolled Keywords: Azole-echinocandin Caspofungin Mucormycosis Posaconazole adrenalin amphotericin B antihistaminic agent dexamethasone hydrocortisone paracetamol abnormal laboratory result adult Article case report clinical feature drug fatality drug withdrawal endoscopic biopsy face edema female follow up generalized edema histopathology human human tissue hypoxemia middle aged patient care planning premedication priority journal respiratory distress tachycardia thorax pain toxic epidermal necrolysis treatment outcome wheezing
Subjects: WR Dermatology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 08 Apr 2020 06:02
Last Modified: 08 Apr 2020 06:02
URI: http://eprints.mums.ac.ir/id/eprint/16611

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