Effect of chronic exposure to cadmium on serum lipid, lipoprotein and oxidative stress indices in male rats

Samarghandian, S. and Azimi-Nezhad, M. and Shabestari, M. M. and Azad, F. J. and Farkhondeh, T. and Bafandeh, F. (2015) Effect of chronic exposure to cadmium on serum lipid, lipoprotein and oxidative stress indices in male rats. Interdisciplinary Toxicology, 8 (3). pp. 151-154.

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Abstract

Cadmium (Cd) is an environmental toxic metal implicated in lipid abnormalities. The present study was designed to elucidate the possible association between chronic exposure to Cd concentration and alterations in plasma lipid, lipoprotein, and oxidative stress indices in rats. Sixteen male rats were assigned to 2 groups of 8 rats each (test and control). The Cd-exposed group obtained drinking water containing cadmium chloride (CdCl2) in the concentration of 2.0 mg Cd/L in drinking water for 3 months. At the end of the experimental period, blood samples were obtained to determine the changes of serum triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), reduced glutathione (GSH), malondialdehyde (MDA) and also serum Cd contents. The results of the present study indicated that Cd administration significantly increased the serum levels of TG, TC, LDL-C, MDA and Cd with reduction in the HDL-C and GSH levels. In conclusion, evidence is presented that chronic exposure to low Cd concentration can adversely affect the lipid and lipoprotein profile via lipid peroxidation. © 2015 Interdisciplinary Toxicology.

Item Type: Article
Additional Information: Cited By :26 Export Date: 16 February 2020 Correspondence Address: Samarghandian, S.; Department of Basic Medical Sciences, Neyshabur University of Medical SciencesIran; email: samarghandians@mums.ac.ir
Uncontrolled Keywords: cadmium lipid lipoprotein oxidative stress cadmium chloride cholesterol drinking water glutathione high density lipoprotein cholesterol low density lipoprotein cholesterol malonaldehyde thiobarbituric acid reactive substance triacylglycerol animal experiment Article blood sampling cholesterol blood level controlled study lipid blood level lipid peroxidation lipoprotein blood level long term exposure male nonhuman rat triacylglycerol blood level
Subjects: QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 08 Apr 2020 06:45
Last Modified: 08 Apr 2020 06:45
URI: http://eprints.mums.ac.ir/id/eprint/16614

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