Improved photostability, reduced skin permeation and irritation of isotretinoin by solid lipid nanoparticles

Shiva, G. and Somaye, M. and Mahmoud Reza, J. (2012) Improved photostability, reduced skin permeation and irritation of isotretinoin by solid lipid nanoparticles. Acta Pharmaceutica, 62 (4). pp. 547-562.

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Abstract

The aim of this study was to develop new solid lipid nanoparticles of isotretinoin (IT-SLNs) and evaluate the ability of IT-SLNs to improve photostability, reduce skin permeation and irritating effects. IT-SLNs were prepared by the hot high pressure homogenization method. Size, zeta potential and morphological characteristics of the preparations were assessed by transmission electron microscopy (TEM) and thermotropic properties with differential scanning calorimetry (DSC). IT-SLNs had a small average diameter of 74.05 ± 8.91 nm and high encapsulation efficiency (EE) of 80.6 ± 1.2 . The results showed that the entrapment of IT into SLNs reduced significantly its photodegradation. The in vitro permeation data showed that IT-SLNs can accumulate in the different layers of the skin and prevent systemic uptake of IT in mouse skin. IT-SLNs also significantly increased IT accumulation in the different layers of the stratum corneum of human skin. IT-SLN formulation was significantly less irritating compared to commercial IT-GEL, which shows its potential for improving skin tolerability and being a carrier for topical delivery of IT.

Item Type: Article
Additional Information: Cited By :19 Export Date: 16 February 2020 CODEN: ACPHE Correspondence Address: Shiva, G.; Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; email: Golmohamadzadehsh@mums.ac.ir
Uncontrolled Keywords: Isotretinoin Photostability Skin irritation Skin permeation SLN glycerol stearate polysorbate 80 solid lipid nanoparticle adult animal tissue article controlled study differential scanning calorimetry drug formulation drug penetration drug stability drug tolerability encapsulation female human human experiment male mouse nonhuman normal human photodegradation rabbit stratum corneum transmission electron microscopy zeta potential Animals Calorimetry, Differential Scanning Drug Carriers Drug Delivery Systems Glycerides Humans Lipids Mice Microscopy, Electron, Transmission Nanoparticles Photolysis Polysorbates Rabbits Skin Skin Absorption Skin Irritancy Tests
Subjects: WR Dermatology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 11 Apr 2020 08:14
Last Modified: 11 Apr 2020 08:14
URI: http://eprints.mums.ac.ir/id/eprint/16618

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