Serum total antioxidant capacity status of HTLV-1 infected patients

Shomali, S. and Zahediahedi Avval, F. and Boostani, R. and Jarahi, L. and Youssefi, M. (2015) Serum total antioxidant capacity status of HTLV-1 infected patients. Acta Virologica, 59 (2). pp. 199-203.

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Many aspects of the pathogenesis of Human T-cell lymphotropic virus type 1 (HTLV-1) still need further elucidations. Previous studies have indicated that oxidative stress occurs during infection with the other retrovirus, human immunodeficiency virus 1 (HIV-1). Similar results have been observed in some other chronic viral infections including hepatitis B (HBV) and hepatitis C (HCV). In order to reveal possible oxidative stress in HTLV-1-infected patients, we evaluated serum total antioxidant capacity (TAC) as an indicator of oxidative stress in these patients. Forty-four HTLV-1-seropositive individuals were included in this study, consisting of 12 symptomatic and 32 asymptomatic (carrier) cases. Controls consisted of 36 apparently healthy, HTLV-1-, HIV- and hepatitis-seronegative individuals. All symptomatic patients had HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Serum TAC levels in patients and healthy individuals were measured using a quantitative TAC assay. The antioxidant capacity in HTLV-1-seropositive cases was significantly reduced compared to control group (P = 0.001). In addition, TAC was lower in patients with more than 5 years history of HAM/TSP compared to those with ≤5 years duration of the myelopathy (P = 0.03). Our results show a depletion of TAC during HTLV-1 infection, which intensifies along with the disease progress. This finding indicates a role of the oxidative stress in pathogenesis of HTLV-1. These results may prompt further research to evaluate any possible therapeutic effect of antioxidant dietary supplements for HTLV-1 infected individuals.

Item Type: Article
Additional Information: Cited By :5 Export Date: 16 February 2020 CODEN: AVIRA Correspondence Address: Youssefi, M.; Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical ScienceIran; email:
Uncontrolled Keywords: HTLV-1 Oxidative stress Total antioxidant capacity (TAC) antioxidant adult antioxidant assay Article blood level clinical article colorimetry comparative study controlled study female human Human T cell leukemia virus infection Human T-lymphotropic virus 1 male middle aged quantitative assay total antioxidant capacity total antioxidant capacity assay tropical spastic paraparesis blood chemistry isolation and purification physiology serum virology Antioxidants HTLV-I Infections Humans
Subjects: WC Communicable Diseases
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 13 Apr 2020 04:53
Last Modified: 13 Apr 2020 04:53

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