Epidemiological Characterization of Drug Resistance among Mycobacterium tuberculosis Isolated from Patients in Northeast of Iran during 2012-2013

Tavanaee Sani, A. and Shakiba, A. and Salehi, M. and Bahrami Taghanaki, H. R. and Ayati Fard, S. F. and Ghazvini, K. (2015) Epidemiological Characterization of Drug Resistance among Mycobacterium tuberculosis Isolated from Patients in Northeast of Iran during 2012-2013. BioMed Research International, 2015.

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Introduction. Tuberculosis is still one of the most important health problems in developing countries and increasing drug resistance is the main concern for its treatment. This study was designed to characterize the drug resistant Mycobacterium tuberculosis isolated from patients suffering from pulmonary tuberculosis in northeast of Iran. Method. In this cross-sectional study during 2012-2013, drug susceptibility testing was performed on Mycobacterium tuberculosis isolated in northeast of Iran using proportional method. Epidemiological data concerning these strains were also analyzed. Results. Among 125 studied isolates, 25 mycobacteria (20) were diagnosed as nontuberculosis mycobacteria. Among the remaining 100 Mycobacterium tuberculosis isolates, the resistance rates were 7, 7, 3, and 9 against isoniazid, rifampin, ethambutol, and streptomycin, respectively. Four isolates were resistant against both isoniazid and rifampin (MDR tuberculosis). The highest resistance rate was observed among 15-45-year-old patients. The MDR tuberculosis was much more prevalent among those who had previous history of treatment. Conclusion. Considering these findings, DOTS strategy should be emphasized and promptly used in order to prevent further resistance. Regarding the high rate of nontuberculosis mycobacteria, it is recommended that confirmatory tests were performed before any therapeutic decision. Copyright © 2015 Ashraf Tavanaee Sani et al.

Item Type: Article
Additional Information: Cited By :6 Export Date: 16 February 2020 Correspondence Address: Ghazvini, K.; Antimicrobial Resistance Research Center, Buali Research Institute and Department of Microbiology and Virology, Mashhad University of Medical SciencesIran
Uncontrolled Keywords: ethambutol isoniazid rifampicin streptomycin adolescent adult aged antibiotic resistance Article bacterial strain bacterium isolate bacterium isolation controlled study cross-sectional study female human Iran lung tuberculosis major clinical study male Mycobacterium tuberculosis nonhuman prevalence atypical Mycobacterium drug effects drug resistance genetics microbial sensitivity test microbiology middle aged pathogenicity pathology Tuberculosis, Multidrug-Resistant Corynebacterineae Humans Microbial Sensitivity Tests Nontuberculous Mycobacteria Rifampin
Subjects: WC Communicable Diseases
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 14 Mar 2020 06:02
Last Modified: 14 Mar 2020 06:02
URI: http://eprints.mums.ac.ir/id/eprint/16641

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