Ultra high resolution optical coherence tomography in Boston type i keratoprosthesis

Zarei-Ghanavati, S. and Betancurt, C. and Mas, A. M. and Wang, J. and Perez, V. L. (2015) Ultra high resolution optical coherence tomography in Boston type i keratoprosthesis. Journal of Ophthalmic and Vision Research, 10 (1). pp. 26-32.

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Purpose: To evaluate the anterior keratoprosthesis-cornea interface in eyes with Boston type I keratoprosthesis (Kpro). Methods: In a prospective non-interventional study, patients with Boston type I Kpro underwent ultra-high resolution optical coherence tomography (UHR-OCT) evaluation. The images were used to measure and describe characteristics of the anterior keratoprosthesis-cornea interface, epithelial interaction at the keratoprosthesis edge and the keratoprosthesis-cornea interface gap. Results: Ten patients including 4 male and 6 female subjects with different preoperative diagnoses, i.e. 8 multiple corneal graft failures and 2 immunological ocular surface diseases, were studied. Mean age was 62.1 ± 20.0 (range, 33.0-83.0) years and mean interval between surgery and UHR-OCT evaluation was 15.2 ± 11.09 months. In eight patients, 360° epithelial growth over the peripheral edge of the Kpro was documented. We detected keratoprosthesis-cornea interface gap in three patients. One subject had developed postoperative endophthalmitis 8 months after surgery and the other two cases were among the high risk group according to the preoperative diagnosis. In one patient with severe ocular hypotony, the Kpro edge was inserted into the anterior stroma and covered with epithelium. Conclusion: UHR-OCT showed that corneal epithelium covers the Kpro edge and seals the potential space between the Kpro and cornea in 80 of cases. The presence of a gap in the interface and lack of epithelial sealing around the Kpro edge might be associated with endophthalmitis.

Item Type: Article
Additional Information: Cited By :9 Export Date: 16 February 2020 Correspondence Address: Perez, V.L.; University of Miami Miller School of Medicine, Bascom Palmer Eye Institute, 900 Northwest 17th Street, United States; email: VPerez4@med.miami.edu
Uncontrolled Keywords: Anterior Segment OCT Boston Type I Keratoprosthesis Ultra High-resolution OCT
Subjects: WN Radiology . Diagnostic Imaging
WR Dermatology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 04 Mar 2020 06:30
Last Modified: 04 Mar 2020 06:30
URI: http://eprints.mums.ac.ir/id/eprint/16686

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