Identification problems with sterile fungi, illustrated by a keratitis due to a non-sporulating Chaetomium-like species

Vinod Mootha, V. and Shahinpoor, P. and Sutton, D. A. and Xin, L. and Najafzadeh, M. J. and De Hoog, G. S. (2012) Identification problems with sterile fungi, illustrated by a keratitis due to a non-sporulating Chaetomium-like species. Medical Mycology, 50 (4). pp. 361-367.

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Abstract

A 39-year-old farm worker was injured in her right eye by a piece of wire, which resulted in a corneal ulcer unresponsive to antibiotic treatment. The clinical appearance was that of a corneal infiltrate with feathery borders resembling fungal keratitis. Corneal scrapings were collected and the patient was started on natamycin 5 eye drops, fluconazole 0.3 eye drops, and oral fluconazole. A non-sporulating fungus was isolated from the samples. Based upon macroscopic and microscopic morphologic features, it was provisionally identified as a Papulaspora species due to the fact that members of this genus generally do not form diagnostically useful conidia. However, it was found through the use of ITS sequencing that the isolate clustered within the ascomycete genus Chaetomium. The sequence did not fully match with any sequences of available ex-type strains of Chaetomium, Thielavia and Papulaspora and hence might belong to an undescribed specie. However, without diagnostic morphological features the taxon cannot be introduced as a novel member of the genus Chaetomium. Antifungal susceptibility testing was performed according to published standards. The corneal ulcer was successfully treated with six weeks of antifungal therapy. © 2012 ISHAM.

Item Type: Article
Additional Information: Cited By :6 Export Date: 16 February 2020 CODEN: MEMYF Correspondence Address: De Hoog, G.S.; CBS-KNAW Fungal Biodiversity Centre, PO Box 85167, 3508 AD Utrecht, Netherlands; email: de.hoog@cbs.knaw.nl
Uncontrolled Keywords: Chaetomium Fungal keratitis Papulaspora atropine bacitracin plus polymyxin B fluconazole natamycin adult antimicrobial therapy article case report cornea ulcer female fungus culture human keratomycosis nonhuman nucleotide sequence ophthalmoscopy Paecilomyces photosensitivity problem identification slit lamp visual acuity visual disorder Antifungal Agents Cluster Analysis Cornea DNA, Fungal DNA, Ribosomal Spacer Humans Keratitis Molecular Sequence Data Mycology Mycoses Phylogeny Sequence Analysis, DNA Wounds and Injuries Fungi Thielavia
Subjects: WW Ophthalmology
QW Microbiology and Immunology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 04 Mar 2020 06:50
Last Modified: 04 Mar 2020 06:50
URI: http://eprints.mums.ac.ir/id/eprint/16689

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