The evaluation of serum copper level in hemodialysis patients with and without anemia compared with healthy controls

Zeraati, A. and Sajad, A. A. and Mahdi, P. S. S. and Farzaneh, S. and Reza, H. and Seifollah, B. M. S. (2015) The evaluation of serum copper level in hemodialysis patients with and without anemia compared with healthy controls. Bangladesh Journal of Medical Science, 14 (1). pp. 43-48.

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Introduction: Anemia is a common complication of ESRD with different etiologies. The most common cause of anemia in such patients is insufficient production of erythropoietin by kidneys. Another possible reason is copper deficiency, thus, this study is aimed to evaluate the serum copper level among hemodialysis patients with and without anemia and to compare them to healthy controls. Material and Methods: A total number of 56 patients who underwent regular hemodialysis due to their ESRD were enrolled and divided into two groups of 28 according to their Hgb results including patients with anemia (Hgb<11 gr/dl) and patients without anemia (Hgb>11 gr/dl). Also, 28 healthy individuals participated as the control group. Venous blood samples were collected from patients prior to hemodialysis. Spectrophotometry employed for copper measurements. Data were analyzed using t-test and Pearson regression analysis. Results: Mean age of patients was 44.36±15.80 years. No significant difference was present among the three groups with regarding to age and gender. Mean and SD of serum copper in patients with anemia, without anemia, and controls were 180.11±54.48, 139.66±35.57 and 155.82±42.06 µg/dl respectively. Serum copper level was significantly higher in hemodialysis patients with anemia compared with those without anemia (p<0.03). Also a significant inverse regression between serum copper and Hgb was present in all hemodialysis patients (p=0.02, r=-0.37). Conclusion: Higher levels of serum copper in anemic patients could be a result of restraining role of high serum copper on iron absorption that has a negative effect on the production of Hgb. However, complementary studies are required. © 2015. Ibn Sina Trust. All Rights Reserved.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Sajad, A.A.; Department of Internal Medicine, Ghaem Hospital, Mashhad University of Medical SciencesIran
Uncontrolled Keywords: Anemia ESRD Hemodialysis Serum copper copper hemoglobin adult Article blood sampling controlled study copper blood level copper deficiency disease association end stage renal disease female hemodialysis patient hemoglobin blood level human iron absorption major clinical study male spectrophotometry treatment duration
Subjects: WJ Urogenital System
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 11 Mar 2020 06:40
Last Modified: 11 Mar 2020 06:40

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