Does at-home bleaching induce systemic oxidative stress in healthy subjects?

Akbari, M. and Nejat, A. H. and Farkhondeh, N. and Mehraban Moghadam, S. and Hashemy, S. I. and Mohammadipour, H. S. (2017) Does at-home bleaching induce systemic oxidative stress in healthy subjects? Australian Dental Journal, 62 (1). pp. 58-64.

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Background: At-home bleaching is a technique characterized by the use of carbamide peroxide or hydrogen peroxide as a tooth-whitening agent. However, no data exist regarding systemic safety of this technique. The aim of this study was to investigate the effect of at-home bleaching on serum redox homeostasis. Methods: Twenty-nine healthy volunteers who requested tooth-whitening participated in this study. Specified bleaching trays were fabricated for the maxilla and mandible arches. Each participant was given two syringes containing 9 hydrogen peroxide gel to use for 30 min/night for 14 nights consecutively. To evaluate the redox status, the serum concentrations of malondialdehyde (MDA), total antioxidant capacity (TAC) and pro-oxidant–antioxidant balance (PAB) were measured. Blood samples were obtained in the morning prior to initiation of study and the morning after expiration of the bleaching period. The collected data were analyzed using Student's t-test with 95 confidence interval. Results: Twenty-three subjects completed the study. MDA, PAB and TAC were significantly increased after the bleaching period (P = 0.001, 0.001 and 0.002, respectively). Conclusions: At-home bleaching revealed the potential to disturb oxidant–antioxidant balance and induce oxidative stress. Its clinical relevance is unfavourable and potential side-effects of at-home bleaching should be considered. © 2016 Australian Dental Association

Item Type: Article
Additional Information: Cited By :2 Export Date: 16 February 2020 CODEN: ADEJA Correspondence Address: Hashemy, S.I.; Surgical Oncology Research Centre, Mashhad University of Medical SciencesIran; email:
Uncontrolled Keywords: Dental bleaching hydrogen peroxide oxidative stress redox carbamide peroxide drug combination malonaldehyde peroxide tooth bleaching agent urea adolescent adult analogs and derivatives blood drug effects female human male middle aged normal human self care young adult Drug Combinations Healthy Volunteers Humans Malondialdehyde Peroxides Tooth Bleaching Agents
Subjects: WU Dentistry. Oral surgery
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib3 lib3
Date Deposited: 18 May 2020 05:06
Last Modified: 18 May 2020 05:06

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