Evaluation of the role of TAX, HBZ, and HTLV-1 proviral load on the survival of ATLL patients

Akbarin, M. M. and Shirdel, A. and Bari, A. and Mohaddes, S. T. and Rafatpanah, H. and Karimani, E. G. and Etminani, K. and Golabpour, A. and Torshizi, R. (2017) Evaluation of the role of TAX, HBZ, and HTLV-1 proviral load on the survival of ATLL patients. Blood Research, 52 (2). pp. 106-111.

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Abstract

Background Adult T-cell leukemia/lymphoma (ATLL) is an aggressive malignancy with very poor prognosis and short survival, caused by the human T-lymphotropic virus type-1 (HTLV-1). The HTLV-1 biomarkers trans-activator x (TAX) and HTLV-1 basic leucine zipper factor (HBZ) are main oncogenes and life-threatening elements. This study aimed to assess the role of the TAX and HBZ genes and HTLV-1 proviral load (PVL) in the survival of patients with ATLL. Methods Forty-three HTLV-1-infected individuals, including 18 asymptomatic carriers (AC) and 25 ATLL patients (ATLL), were evaluated between 2011 and 2015. The mRNA expression of TAX and HBZ and the HTLV-1 PVL were measured by quantitative PCR. Results Significant differences in the mean expression levels of TAX and HBZ were observed between the two study groups (ATLL and AC, P =0.014 and P=0.000, respectively). In addition, the ATLL group showed a significantly higher PVL than AC (P=0.000). There was a significant negative relationship between PVL and survival among all study groups (P =0.047). Conclusion The HTLV-1 PVL and expression of TAX and HBZ were higher in the ATLL group than in the AC group. Moreover, a higher PVL was associated with shorter survival time among all ATLL subjects. Therefore, measurement of PVL, TAX, and HBZ may be beneficial for monitoring and predicting HTLV-1-infection outcomes, and PVL may be useful for prognosis assessment of ATLL patients. This research demonstrates the possible correlation between these virological markers and survival in ATLL patients. © 2017 Korean Society of Hematology.

Item Type: Article
Additional Information: Cited By :1 Export Date: 16 February 2020 Correspondence Address: Torshizi, R.; Department of Modern Sciences and Technologies, Mashhad University of Medical SciencesIran; email: torshiziR901@mums.ac.ir
Uncontrolled Keywords: ATLL HBZ HTLV-1 Proviral load TAX calcium cyclophosphamide dexamethasone doxorubicin prednisone Tax protein vincristine adult Article calcium blood level cancer combination chemotherapy cancer patient cancer survival clinical article edema female gene expression gene function HBZ gene hepatomegaly human human cell Human T-lymphotropic virus 1 lymphadenopathy male middle aged nonhuman polymerase chain reaction post treatment survival quantitative analysis skin defect splenomegaly survival time T cell leukemia virus gene virus load
Subjects: WH Hemic and Lymphatic System
QU Biochemistry
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib3 lib3
Date Deposited: 18 May 2020 04:20
Last Modified: 18 May 2020 04:20
URI: http://eprints.mums.ac.ir/id/eprint/16734

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