Recent strategies for the management of renal angiomyolipoma: A review of diagnostic and therapeutic approaches

Akhavan Rezayat, A. and Aslezare, M. and Ahmadnia, H. and Soltani, S. and Asadpour, A. (2017) Recent strategies for the management of renal angiomyolipoma: A review of diagnostic and therapeutic approaches. Nephro-Urology Monthly, 9 (6).

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Recent prophylactic treatment options and diagnostic tools show a suboptimal improvement in patients with renal angiomyolipoma (AML). This study was an attempt to review management strategies applied before invasive options. An extensive research on medical databases such as PubMed and Scopus was performed from 1999 to 2016 using the following keywords: ‘kidney’, ‘renal’, and ‘angiomyolipoma’. All related studies on patients treating with conservative or minimally-invasive procedures were included. However, reports on surgical treatments were excluded. Treatment strategies have been selected based on outcomes resulting from computed tomography (CT) and magnetic resonance (MR) imaging. Fat content and tumor size are the most common used indications for AMLs. Unenhanced CT and chemical shift imaging provide good evidence in case of fat-poor AMLs. Chemical analysis and percutaneous biopsy are recommended in case of a diagnostic challenge. A tumor size of 6 cm or larger in diameter might necessitate invasive treatment, while AMLs patients with tumors around 4cmmay require prophylactic treatment. Of all treatment options, embolization indicated a high risk of reintervention. Moreover, everolimus and sirolimus as 2 inhibitors of mammalian target of rapamycin (mTOR) have been evaluated in clinical trials and demonstrated promising outcomes. In conclusion, advances in imaging techniques along with mTOR inhibitors and embolic materials potentiate functional outcomes in AMLs. © 2017, Nephro-Urology Monthly.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Asadpour, A.; Ghaem HospitalIran; email:
Uncontrolled Keywords: Angiomyolipoma Embolization Fat Imaging Kidney Reintervention everolimus melan A placebo rapamycin smooth muscle actin acne anemia artificial embolization cancer staging computer assisted tomography conservative treatment differential diagnosis echography hematuria histopathology human hyperlipidemia immunohistochemistry incidental finding kidney tumor mouth ulcer nuclear magnetic resonance imaging partial nephrectomy percutaneous biopsy peripheral edema prophylaxis radiofrequency ablation renal angiomyolipoma Review rhinopharyngitis stomatitis subependymal giant cell astrocytoma tuberous sclerosis tumor recurrence tumor regression tumor volume
Subjects: WJ Urogenital System
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib3 lib3
Date Deposited: 18 May 2020 06:38
Last Modified: 18 May 2020 06:38

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