Structure-function relationships in perimetric glaucoma: Comparison of minimum-rim width and retinal nerve fiber layer parameters

Amini, N. and Daneshvar, R. and Sharifipour, F. and Romero, P. and Henry, S. and Caprioli, J. and Nouri-Mahdavi, K. (2017) Structure-function relationships in perimetric glaucoma: Comparison of minimum-rim width and retinal nerve fiber layer parameters. Investigative Ophthalmology and Visual Science, 58 (11). pp. 4623-4631.

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Abstract

PURPOSE. To test the hypotheses that: (1) structure-function (SF) relationships between visual fields (VF) and Bruch’s membrane opening-based minimum rim width (BMO-MRW) measurements are superior to those for peripapillary retinal nerve fiber layer (pRNFL) in perimetric glaucoma; (2) BMO-MRW measurements may extend the utility of structural measurement across the range of glaucoma severity; and (3) to estimate the influence of Bruch’s membrane opening (BMO) size on BMO-MRW measurements. METHODS. One hundred eight perimetric glaucoma eyes (68 patients) with good quality spectral-domain optical coherence tomography images of the optic disc and pRNFL, and reliable VF within 6 months were recruited. Relationship of global and sectoral BMO-MRW and pRNFL thickness with corresponding VF parameters and the influence of normalizing BMO-MRW (on BMO circumference, nBMO-MRW) on SF relationships were investigated. Broken-stick models were used to compare the point at which pRNFL and BMO-MRW parameters reached their measurement floor. RESULTS. The median (interquartile range) of VF mean deviation was -5.9 (-12.6 to -3.6) dB. Spearman correlation coefficients between pRNFL, BMO-MRW, and nBMO-MRW measures and corresponding VF cluster average deviations ranged between 0.55 to 0.80, 0.35 to 0.66, and 0.38 to 0.65, respectively. Bruch’s membrane opening-MRW parameters demonstrated weaker SF relationships compared with pRNFL globally and in temporal, temporal-superior, and nasal-inferior sectors (P < 0.03). Normalization of BMO-MRW did not significantly influence SF relationships. CONCLUSIONS. Structure-function relationships were somewhat weaker with BMO-MRW parameters compared with pRNFL in eyes with perimetric glaucoma. Bruch’s membrane opening-MRW normalization did not significantly change SF relationships in this group of eyes with mild departures from average BMO size. © 2017 The Authors.

Item Type: Article
Additional Information: Cited By :3 Export Date: 16 February 2020 CODEN: IOVSD Correspondence Address: Nouri-Mahdavi, K.; Stein Eye Institute, 100 Stein Plaza, United States; email: nouri-mahdavi@jsei.ucla.edu
Uncontrolled Keywords: BMO-MRW Glaucoma Optical coherence tomography RNFL aged Article Bruch membrane bruchs membrane opening based minimum rim width disease severity female human major clinical study male optic disk priority journal retinal nerve fiber layer parameters spectral domain optical coherence tomography visual field visual system parameters comparative study diagnostic imaging open angle glaucoma pathology retina nerve cell severity of illness index Glaucoma, Open-Angle Humans Retinal Neurons Tomography, Optical Coherence Visual Fields
Subjects: WW Ophthalmology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib3 lib3
Date Deposited: 18 May 2020 06:53
Last Modified: 18 May 2020 06:53
URI: http://eprints.mums.ac.ir/id/eprint/16742

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