Cognitive-behavioral therapy for opiate users in methadone treatment: A multicenter randomized controlled trial

Amini-Lari, M. and Alammehrjerdi, Z. and Ameli, F. and Joulaei, H. and Daneshmand, R. and Faramarzi, H. and Bakhtiyari, H. R. and Samadi, R. (2017) Cognitive-behavioral therapy for opiate users in methadone treatment: A multicenter randomized controlled trial. Iranian Journal of Psychiatry and Behavioral Sciences, 11 (2).

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Background: Opiate use on a stable methadone dose is a health concern in Iran (Persia). Cognitive-behavioral therapy (CBT) is a suggested treatment for this problem. Objectives: The study aimed to assess the CBT effectiveness in the treatment of regular opiate use on a stable methadone dose in Shiraz, near the Persian Gulf of Iran. Methods: The study design was a multicenter randomized controlled trial. The study was conducted at two methadone clinics during 2015. Overall, 118 patients who were regular opiate users were selected. Participants were randomly assigned (1:1) to receive either CBT (n = 59) or remain in a control condition (n = 59). The Opiate Treatment Index, Contemplation Ladder and Severity of Dependence Scale were completed at baseline, post-treatment and a three-month follow-up. The primary outcome was the reduced mean score of regular opiate use. Other outcomes included an increased readiness to reduce opiate use and reduced severity of opiate dependence. Data were analyzed performing intentions-to-treat analyses, independent samples t-tests and Wilcoxon Rank- Sum tests. Results: CBT significantly reduced opiate use (z = 3.73, P = 0.01, d = 0.89) and the severity of opiate dependence (z = 7.36, P = 0.01, d = 0.64) after four weeks of treatment. Readiness to reduce opiate use significantly increased (t (116) = 9.55, P = 0.01, d = 0.81) over the same time. All study results remained stable at three-month follow-up while no significant change was found in the control group. Conclusions: CBT can be used as an effective intervention to reduce regular opiate use on a stable methadone dose. A larger study with more Persian participants and a six-month follow-up is suggested. © 2017, Mazandaran University of Medical Sciences.

Item Type: Article
Additional Information: Cited By :3 Export Date: 16 February 2020 Correspondence Address: Amini-Lari, M.; Shiraz HIV/AIDS Research Center, Health Institute, Shiraz University of Medical Sciences, Lavan Ave, Delavaran-e Basij Blvd, Khatoun Sq, Iran; email:
Uncontrolled Keywords: Cognitive-Behavioral therapy Iran Methadone therapy Substance use disorders methadone adult Article cognitive behavioral therapy Contemplation Ladder controlled study disease severity female follow up human intention to treat analysis major clinical study male methadone treatment multicenter study opiate addiction Opiate Treatment Index questionnaire randomized controlled trial rating scale scoring system Severity of Dependence Scale treatment outcome
Subjects: WM Psychiatry
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib3 lib3
Date Deposited: 18 May 2020 05:30
Last Modified: 18 May 2020 05:30

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