Amelioration of patients with chronic spontaneous urticaria in treatment with vitamin D supplement

Ariaee, N. and Zarei, S. and Mohamadi, M. and Jabbari, F. (2017) Amelioration of patients with chronic spontaneous urticaria in treatment with vitamin D supplement. Clinical and Molecular Allergy, 15 (1).

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Abstract

Background: Spontaneous urticaria is a common allergic skin condition affecting 0.5-1 of individuals and may burden on health care expenditure or may be associated with remarkable morbidity. Aim: In this study, we measured the effect of vitamin D supplementation in patients with a diagnosis of CSU. Furthermore, quality of life and cytokine changes were evaluated. Methods: The clinical trial was conducted on 20 patients with idiopathic chronic urticaria. Vitamin D was administered orally for 8 weeks and disease activity was measured pre- and post-treatment using USS and DLQI. On the other hand expressions of IL-17, IL-10, Foxp3, and TGF-β by Real-time RT-PCR were assessed. Results: USS questionnaire showed that severity of idiopathic urticaria after the intervention, which compared with the first day reached a significant 55 reduction. The DLQI quality of life questionnaire 2 months after treatment showed 55 improvement. Along with the significant improvement of clinical symptoms, use of vitamin D increase FOXP3 gene expression and downregulation of IL-10, TGF-B, and FOXP3, IL-17, but these changes were not statistically significant. Limitation: These might happen due to lack of enrolled population in the investigation. Conclusion: Vitamin D can be used along with standard medical care and it's a safe and cost-effective method for the treatment of chronic urticaria with deficiency of vitamin D. © 2018 The Author(s).

Item Type: Article
Additional Information: Cited By :2 Export Date: 16 February 2020 Correspondence Address: Jabbari, F.; Allergy Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Shariati Square, Iran; email: Jabbarif@mums.ac.ir
Uncontrolled Keywords: Spontaneous chronic urticaria T reg Vitamin D antihistaminic agent interleukin 10 interleukin 17 transcription factor FOXP3 transforming growth factor beta adolescent adult Article chronic urticaria clinical article controlled clinical trial controlled study cost effectiveness analysis disease activity disease severity down regulation drug megadose drug safety female FOXP3 gene gene gene expression human male protein expression quality of life assessment questionnaire real time polymerase chain reaction reverse transcription polymerase chain reaction symptom treatment duration vitamin supplementation
Subjects: WD Nutrition Disease and metabolic diseases
WR Dermatology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib3 lib3
Date Deposited: 18 May 2020 05:45
Last Modified: 18 May 2020 05:45
URI: http://eprints.mums.ac.ir/id/eprint/16749

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