Seroprevalence of hepatitis E virus in blood donors in Khuzestan Province, Southwest Iran

Assarehzadegan, M. A. and Shakerinejad, G. and Amini, A. and Rezaee, S. A. R. (2008) Seroprevalence of hepatitis E virus in blood donors in Khuzestan Province, Southwest Iran. International Journal of Infectious Diseases, 12 (4). pp. 387-390.

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Objective: To determine the seroprevalence of hepatitis E virus (HEV) infection among volunteer blood donors in Khuzestan Province, Iran. Khuzestan is a war stricken area in the southwest of Iran, which shares a land, river, and sea border with Iraq. This region has suffered the heaviest public health system damage of all the Iranian provinces during a 25-year period of war and conflict. Methods: A cross-sectional study was carried out among 400 urban volunteer blood donors of the regional blood banks, from May to December 2005. Serum samples from healthy blood donors were tested for IgG anti-HEV antibody using a specific enzyme linked immunoassay (ELISA) kit. Results: The prevalence of HEV infection was found to be 11.5 (46/400). All patients were negative for anti-HIV, anti-HBV, and anti-HCV antibodies. The data indicate that 14.6 (38/260) of HEV positive subjects were male, compared to 5.7 (8/140) of females; this difference is statistically significant (risk ratio = 2.6, p < 0.008). Conclusions: These findings demonstrate the high prevalence rate of anti-HEV among blood donors, particularly males. © 2007 International Society for Infectious Diseases.

Item Type: Article
Additional Information: Cited By :34 Export Date: 16 February 2020 CODEN: IJIDF Correspondence Address: Assarehzadegan, M.A.; Department of Immunology, Faculty of Medicine, Ahwaz Joundishapur University of Medical Sciences, Ahwaz, Iran; email:
Uncontrolled Keywords: Blood donor Hepatitis E virus Iran Khuzestan Seroprevalence hepatitis E antibody immunoglobulin G antibody adult age distribution article blood bank cross-sectional study enzyme linked immunosorbent assay female hepatitis E human major clinical study male sex ratio statistical analysis volunteer war Adolescent Blood Donors Cross-Sectional Studies Humans Middle Aged Seroepidemiologic Studies Serologic Tests Sex Distribution
Subjects: WC Communicable Diseases
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib3 lib3
Date Deposited: 18 May 2020 03:34
Last Modified: 18 May 2020 03:34

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