Assessment of BAALC gene expression in acute myeloid leukemia patients compared to control group in North-East of Iran

Ayatollahi, H. and Rahimi, H. and Jafarian, A. H. and Allahyari, A. and Sadeghian, M. H. and Keramati, M. R. and Sheikhi, M. and Amini, N. and Amirpour, M. and Shakeri, S. and Shams, S. F. and Bahrami, A. (2017) Assessment of BAALC gene expression in acute myeloid leukemia patients compared to control group in North-East of Iran. UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi, 27 (4). pp. 237-243.

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Acute myeloid leukemia (AML) is recognized as one of the most common types of leukemia among adults. This condition is characterized by the uncontrolled proliferation of myeloid progenitors, affecting the normal function of different systems in the human body. Various factors such as genetic abnormalities, exposure to chemicals, and viruses can induce AML. Expression of NPM1, CEBPA, MN1, and BAALC genes is among important genetic factors affecting AML prognosis and diagnosis. The aim of this study was to assess amount of BAALC gene expression in AML patients and its relation to survival rate. This case-control study was performed at Mashhad University of Medical Sciences, Mashhad, Iran. 56 AML patients and 56 healthy individuals were participated in this research. The level of BAALC gene expression was assessed by real-time polymerase chain reaction (RT-PCR) method; GPI gene was used as the control. For statistical analysis, SPSS version 21 was applied. P-value less than 0.05 was considered statistically significant. In total, 55.3 and 44.7 of the participants were male and female, respectively. BAALC gene up- and down-regulation was reported in 28.6 and 71.4 of AML cases, respectively. BAALC gene expression and hematological parameters were significantly different between the two groups (p< 0.05). Based on the findings, the survival rate was estimated at 31 and 39 months in patients with BAALC up- and down-regulation, respectively. BAALC gene over expression could be considered as a predictive factor for poor prognosis and reduced survival in AML patients. © 2017, UHOD - Uluslararasi Hematoloji Onkoloji Dergisi. All rights reserved.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Amirpour, M.; Department of Hematology and Blood Banking, Student Research Committee, School of Medicine, Mashhad University of Medical SciencesIran; email:
Uncontrolled Keywords: Acute myeloid leukemia BAALC Down-regulation RT-PCR Survival rate Up-regulation brain and acute leukemia cytoplasmic protein hemoglobin peptides and proteins unclassified drug adult Article BAALC gene bleeding case control study controlled study DNA synthesis down regulation erythrocyte count female gene gene control gene expression hematocrit hepatomegaly human leukocyte count lymphadenopathy major clinical study male mean corpuscular hemoglobin mean corpuscular volume petechia purpura real time polymerase chain reaction RNA extraction spectrophotometry splenomegaly thrombocyte count upregulation
Subjects: QU Biochemistry
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib3 lib3
Date Deposited: 18 May 2020 05:39
Last Modified: 18 May 2020 05:39

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