Prognostic Importance of C-KIT Mutations in Core Binding Factor Acute Myeloid Leukemia: A Systematic Review

Ayatollahi, H. and Shajiei, A. and Sadeghian, M. H. and Sheikhi, M. and Yazdandoust, E. and Ghazanfarpour, M. and Shams, S. F. and Shakeri, S. (2017) Prognostic Importance of C-KIT Mutations in Core Binding Factor Acute Myeloid Leukemia: A Systematic Review. Hematology/ Oncology and Stem Cell Therapy, 10 (1). pp. 1-7.

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Objective/background Acute myeloid leukemia (AML) is defined as leukemic blast reproduction in bone marrow. Chromosomal abnormalities form different subgroups with joint clinical specifications and results. t(8;21)(q22;q22) and inv(16)(p13;q22) form core binding factor-AML (CBF-AML). c-kit mutation activation occurs in 12.8–46.1 of adults with CBF leukemia. These mutations occur in 20–25 of t(8;21) and 30 of inv(16) cases. Methods In this systematic review, we searched different databases, including PubMed, Scopus, and Embase. Selected articles were measured based on the inclusion criteria of this study and initially compared in terms of titles or abstracts. Finally, articles relevant to the subject of this review were retrieved in full text. Twenty-two articles matched the inclusion criteria and were selected for this review. Results In this study, c-kit mutations were associated with poor prognosis in AML patients with t(8;21) and inv(16). In addition, these mutations had better prognostic effects on AML patients with inv(16) compared with those with t(8;21). Conclusion According to the results of this study, c-kit mutations have intense, harmful effects on the relapse and white blood cell increase in CBF-AML adults. However, these mutations have no significant prognostic effects on patients. © 2016 King Faisal Specialist Hospital & Research Centre

Item Type: Article
Additional Information: Cited By :22 Export Date: 16 February 2020 Correspondence Address: Sheikhi, M.; Cancer Molecular Pathology Research Center, Ghaem Hospital, Shariati SqIran; email:
Uncontrolled Keywords: c-kit CBF-AML inv(16) t(8 21) core binding factor stem cell factor receptor acute myeloid leukemia cancer patient cancer prognosis gene mutation human leukemia relapse leukocyte oncogene c kit Review systematic review chromosome inversion factual database gene translocation genetics mortality mutation pathology prognosis survival rate Databases, Factual Humans Leukemia, Myeloid, Acute Proto-Oncogene Proteins c-kit Translocation, Genetic
Subjects: WH Hemic and Lymphatic System
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib3 lib3
Date Deposited: 18 May 2020 03:52
Last Modified: 18 May 2020 03:52

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