The level of urinary endothelin in patients with urinary reflux

Azarfar, A. and Esmaeeli, M. and Naseri, M. and Badiee Aval, S. and Ghanee Sharbaf, F. and Ravanshad, S. and Ravanshad, Y. and Mehrad-Majd, H. and Molkara, S. (2017) The level of urinary endothelin in patients with urinary reflux. Journal of Nephropathology, 6 (4). pp. 356-358.

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Background: In different tissues, the endothelin is produced by vascular endothelium. They are potent vasoconstrictor peptides. There is a little information about the role of endothelin in reflux nephropathy. Objectives: The aim of this study is to evaluate urinary levels of endothelin in patients with vesicoureteral reflux (VUR). Patients and Methods: It was a cross-sectional study that conducted on 81 children who received voiding cystourethrogram (VCUG). Based on VCUG reports, patients were divided into two groups; with reflux (40 persons) and without reflux (41 persons). We got a urine sample from patients with mid-stream or urine bag method. The endothelin level was assessed with ELISA immunoassay. Data was analyzed using SPSS 16. Results: Based on VCUG reports, 40 patients (49.4) had urinary reflux, of them 20 cases suffered from unilateral urinary reflux and others from bilateral. Of 40 patients with reflux, 23 cases (57.5 of reflux group) had kidney scar and seven individuals (17.5) had abnormal kidney sonography. Of patients with urinary reflux, 13 cases (32.5) had grade1 urinary reflux, 8 cases (20) grade 2, and 5 cases (12.5) grade 3 and finally 14 cases (35) grade 4. The UET-1 levels were significantly higher in VUR patients compared to the control group (P < 0.001). Comparison of mean endothelin levels between two groups was done using Mann-Whitney U test and was statistically significance (P < 0.001). We used Kruskal-Wallis for comparison of endothelin levels in different grades of reflux (P < 0.001). Conclusions: Urine endothelin-1 level can be considered as an alternative to VCUG for screening vesicourethral reflux. © 2017 The Author(s); Published by Society of Diabetic Nephropathy Prevention.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Ravanshad, Y.; Clinical Research Unit, Mashhad University of Medical SciencesIran; email:
Uncontrolled Keywords: Chronic renal failure Endothelin Reflux Vesicoureteral reflux Voiding cystourethrography biological marker vasoconstrictor agent Article chronic kidney failure cross-sectional study echography enzyme linked immunosorbent assay female human human tissue kidney scar major clinical study male micturition cystourethrography reflux nephropathy urine sampling vascular endothelium
Subjects: WJ Urogenital System
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib3 lib3
Date Deposited: 23 May 2020 07:08
Last Modified: 23 May 2020 07:08

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