A review on fast dissolving systems: From tablets to nanofibers

Bahrainian, S. and Abbaspour, M. and Kouchak, M. and Moghadam, P. T. (2017) A review on fast dissolving systems: From tablets to nanofibers. Jundishapur Journal of Natural Pharmaceutical Products, 12 (2).

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Abstract

Context: Oral administration of drugs remains the most common and preferred route for many active pharmaceutical ingredients (APIs). However, solid oral dosage formsmaybe limited for patientswhohave swallowing problems or fear of choking. Furthermore in the case of solid dosage forms, disintegration and dissolution of dosage forms are rate limiting steps mostly for hydrophobic drugs' absorption and bioavailability. Liquid oral dosage forms such as syrups, emulsions or suspensions may be used to overcome these disadvantages but higher costs of their production and larger volume and dimensions of their packaging along with the lower precision in dose intake make the liquid oral dosage form less acceptable for patients and pharmaceutical industries. Evidence Acquisition: In order to merge the advantages of both solid and liquid oral dosage forms, fast dissolving drug delivery systems have been developed over the years. The current review aimed to discuss the pros and cons of different preparations of oral fast dissolving dosage forms including tablets, films and nanofibers. Results: Fast dissolving dosage forms rapidly dissolve in mouth without the need for additional liquid or chewing, providing ease of use for consumers, a fast absorption of drug, quick onset of action, and improved bioavailability. Various technologies to fabricate these dosage forms such as lyophilization, spray drying, solvent casting, hot melt extrusion, compaction and electrospinning are also addressed. Conclusions: Fast dissolving drug delivery systems are the promising approach in oral drug delivery systems, which can provide patient compliance especially in case of pediatrics and geriatrics. They can also lead to quick action of drugs and enhanced bioavailability. © 2016, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences.

Item Type: Article
Additional Information: Cited By :2 Export Date: 16 February 2020 Correspondence Address: Bahrainian, S.; Student Research Committee, Ahvaz Jundishapur University of Medical SciencesIran; email: sara.bahrainian@yahoo.com
Uncontrolled Keywords: Drug Delivery Systems Nanofibers Solubility Tablets adhesive agent central stimulant agent coloring agent disintegrating agent filler flavoring agent lubricating agent nanofiber plasticizer polymer defense mechanism dispersion drug delivery system drug dosage form drug manufacture drug solubility electrospinning freeze drying hot melt extrusion human Review solvent casting spray drying tablet tablet compression
Subjects: QU Biochemistry
QV pharmacology
W General medicine- Health professions
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib3 lib3
Date Deposited: 18 May 2020 05:54
Last Modified: 18 May 2020 05:54
URI: http://eprints.mums.ac.ir/id/eprint/16768

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