Distribution of different sized ocular surface vessels in diabetics and normal individuals

Banaee, T. and Pourreza, H. and Doosti, H. and Abrishami, M. and Ehsaei, A. and Basiry, M. and Pourreza, R. (2017) Distribution of different sized ocular surface vessels in diabetics and normal individuals. Journal of Ophthalmic and Vision Research, 12 (4). pp. 361-367.

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Abstract

Purpose: To compare the distribution of different sized vessels using digital photographs of the ocular surface of diabetic and normal individuals. Methods: In this cross-sectional study, red-free conjunctival photographs of diabetic and normal individuals, aged 30-60 years, were taken under defined conditions and analyzed using a Radon transform-based algorithm for vascular segmentation. The image areas occupied by vessels (AOV) of different diameters were calculated. The main outcome measure was the distribution curve of mean AOV of different sized vessels. Secondary outcome measures included total AOV and standard deviation (SD) of AOV of different sized vessels. Results: Two hundred and sixty-eight diabetic patients and 297 normal (control) individuals were included, differing in age (45.50 ± 5.19 vs. 40.38 ± 6.19 years, P < 0.001), systolic (126.37 ± 20.25 vs. 119.21 ± 15.81 mmHg, P < 0.001) and diastolic (78.14 ± 14.21 vs. 67.54 ± 11.46 mmHg, P < 0.001) blood pressures. The distribution curves of mean AOV differed between patients and controls (smaller AOV for larger vessels in patients; P < 0.001) as well as between patients without retinopathy and those with non-proliferative diabetic retinopathy (NPDR); with larger AOV for smaller vessels in NPDR (P < 0.001). Controlling for the effect of confounders, patients had a smaller total AOV, larger total SD of AOV, and a more skewed distribution curve of vessels compared to controls. Conclusion: Presence of diabetes mellitus is associated with contraction of larger vessels in the conjunctiva. Smaller vessels dilate with diabetic retinopathy. These findings may be useful in the photographic screening of diabetes mellitus and retinopathy. © 2017 Journal of Ophthalmic and Vision Research | Published by Wolters Kluwer - Medknow.

Item Type: Article
Additional Information: Cited By :2 Export Date: 16 February 2020 Correspondence Address: Banaee, T.; Retina Research Center, Mashhad University of Medical Sciences, Khatam-Al-Anbia Hospital, Abutaleb Junction, Ghareni Blvd., Iran; email: tkbanaee@gmail.com
Subjects: WK Endocrine System
WW Ophthalmology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib3 lib3
Date Deposited: 13 May 2020 08:22
Last Modified: 13 May 2020 08:22
URI: http://eprints.mums.ac.ir/id/eprint/16775

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