The value of serum pro-oxidant/antioxidant balance in the assessment of asphyxia in term neonates

Boskabadi, H. and Zakerihamidi, M. and Heidarzadeh, M. and Avan, A. and Ghayour-Mobarhan, M. and Ferns, G. A. (2017) The value of serum pro-oxidant/antioxidant balance in the assessment of asphyxia in term neonates. Journal of Maternal-Fetal and Neonatal Medicine, 30 (13). pp. 1556-1561.

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Objective: Asphyxia is a major cause of disabilities in term-born infants. Here we have explored the value in HIE (hypoxic-ischemic-encephalopathy) of using a combination of serum pro-oxidant/antioxidant balance (PAB) assay for predicting the prognosis of asphyxia. Method: Ninety term neonates with asphyxia were enrolled and followed up for two years. Serum PAB, demographic/biochemical characteristics of mothers, and their neonates were determined. The Denver II test was used to assess outcomes. Results: Of the 90 asphyxiated neonates, 47 (52.2) had a normal outcome and 43 babies (47.8) had abnormal outcome. Serum PAB levels in neonates with normal and abnormal outcomes were 17.1 ± 9.23 and 48.27 ± 41.30 HK, respectively. A combination of HIE intensity and PAB, compared to other indicators, had a higher predictive-value (95.2) for outcomes in asphyxiated babies. Conclusion: We demonstrate that PAB in combination with HIE grade may have a better predictive value for the prognosis of asphyxiated babies and predicting future neurologic problems in asphyxiated term infants. © 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

Item Type: Article
Additional Information: Export Date: 16 February 2020 CODEN: JMNMA Correspondence Address: Zakerihamidi, M.; Reproductive Health, Department of Midwifery, School of Medicine, Tonekabon Branch, Islamic Azad UniversityIran; email:
Uncontrolled Keywords: Asphyxia hypoxic ischemic encephalopathy newborn PAB balance Article controlled study demography Denver Developmental Screening Test diagnostic test accuracy study female follow up human major clinical study male newborn hypoxia observational study outcome assessment physical parameters predictive value priority journal prognosis prooxidant antioxidant balance prospective study receiver operating characteristic sensitivity and specificity Apgar score blood brain hypoxia case control study complication pregnancy severity of illness index antioxidant oxidizing agent Antioxidants Asphyxia Neonatorum Case-Control Studies Humans Hypoxia, Brain Infant, Newborn Oxidants Prospective Studies ROC Curve
Subjects: WH Hemic and Lymphatic System
WS Pediatrics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib3 lib3
Date Deposited: 18 May 2020 03:19
Last Modified: 18 May 2020 03:19

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