Nucleated red blood cells count as a prognostic biomarker in predicting the complications of asphyxia in neonates

Boskabadi, H. and Zakerihamidi, M. and Sadeghian, M. H. and Avan, A. and Ghayour-Mobarhan, M. and Ferns, G. A. (2017) Nucleated red blood cells count as a prognostic biomarker in predicting the complications of asphyxia in neonates. Journal of Maternal-Fetal and Neonatal Medicine, 30 (21). pp. 2551-2556.

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Objective: Nucleated-red-blood-cells (NRBC) count in umbilical cord of newborns is been suggested as a sign of birth asphyxia. The present study was conducted to explore the value of NRBC count in prognosis of asphyxiated neonates. Methods: Sixty-three neonates with asphyxia were followed up for two years. Maternal and neonatal information was recorded follow by clinical and laboratory evaluation. NRBC-level was determined per 100 white-blood-cells (WBC). After discharge, follow-up of asphyxiated infants was performed using Denver II test at 6, 12, 18 and 24 months. Neonates were divided into two groups, with favorable and unfavorable outcome based on developmental delay or death. Results: We observed that NRBC count with more than 11 per 100 WBC, had sensitivity of 85 and specificity of 90 in predicting complications of asphyxia, while in absolute NRBC count with more than 1554, the sensitivity and specificity were 85 and of 87, respectively. Combination of NRBC + HIE (hypoxic ischemic encephalopathy) grade had a high-predictive power for determining the prognosis of asphyxia in neonates. Conclusion: We demonstrate that NRBC/100 WBC and absolute NRCB count can be used as prognostic marker for neonatal asphyxia, which in combination with the severity of asphyxia could indicate high infant mortality, and complications of asphyxia. Further studies in a larger and multi center setting trail are warranted to investigate the value of NRBC and HIE in asphyxiate term infants. © 2016 The Author(s).

Item Type: Article
Additional Information: Cited By :4 Export Date: 16 February 2020 CODEN: JMNMA Correspondence Address: Zakerihamidi, M.; Department of Midwifery, School of Medicine, Tonekabon Branch Islamic Azad UniversityIran; email:
Uncontrolled Keywords: Asphyxia Hypoxic ischemic encephalopathy Neonates Nucleated red blood cells biological marker Article artificial ventilation cohort analysis Denver Developmental Screening Test developmental delay disease severity erythrocyte count female follow up human human cell infant mortality leukocyte major clinical study male mortality rate newborn newborn hypoxia nucleated red blood cell count outcome assessment predictive value priority journal prognosis prognostic assessment receiver operating characteristic sensitivity and specificity adolescent adult blood complication developmental disorder erythroblast young adult Asphyxia Neonatorum Biomarkers Developmental Disabilities Erythroblasts Follow-Up Studies Humans Infant, Newborn
Subjects: WF Respiratory System
WH Hemic and Lymphatic System
WS Pediatrics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib3 lib3
Date Deposited: 18 May 2020 09:14
Last Modified: 18 May 2020 09:14

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