Improvement in symptoms and pulmonary function of asthmatic patients due to their treatment according to the Global Strategy for Asthma Management (GINA)

Boskabady, M. H. and Rezaeitalab, F. and Rahimi, N. and Dehnavi, D. (2008) Improvement in symptoms and pulmonary function of asthmatic patients due to their treatment according to the Global Strategy for Asthma Management (GINA). BMC Pulmonary Medicine, 8.

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Abstract

Background: Global Initiative Strategy for Asthma Management (GINA) is poorly applied in undeveloped and developing countries. The current study examined the effects of applying GINA guidelines on treatment efficacy in asthmatic patients in Iran. Methods: Twenty four asthmatic patients (usual care group) were treated as usual and 26 patients (intervention group) according to the GINA for 2 months. Asthma symptom score, asthma severity, frequency of symptoms/ week and wheezing were recorded at the beginning (first visit), one month after treatment (second visit), and at the end of the study (third visit). Pulmonary function tests (PFTs) were performed by spirometry, and the patients' use of asthma drugs and their symptoms were evaluated, at each visit. Results: Asthma symptoms, frequency of symptoms/week, chest wheezing, and PFT values were significantly improved in the intervention group at the second and third visits compared to first visit (p < 0.001 for all measures). In addition, exercise induced cough and wheeze were significant improved in the third visit compared to the second visit in this group (p < 0.01 for both measures). In the second and third visits all symptoms were significantly lower, and PFT values higher, in the intervention group compared to the usual care group (p < 0.005 to p < 0.001). In the usual care group, there were only small improvements in some parameters in just the second visit (p < 0.01 for all measures). The use of asthma drugs was unchanged in the usual care group and significantly reduced in the intervention group (p < 0.01) by the end of the study. Conclusion: Adoption of GINA guidelines improves asthma symptoms and pulmonary function in asthmatic patients in Iran. © 2008 Boskabady et al; licensee BioMed Central Ltd.

Item Type: Article
Additional Information: Cited By :5 Export Date: 16 February 2020 CODEN: BPMMB Correspondence Address: Boskabady, M.H.; Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad, Iran; email: m-boskabady@mums.ac.ir
Uncontrolled Keywords: beclometasone dipropionate beta adrenergic receptor stimulating agent corticosteroid fluticasone methylxanthine salbutamol theophylline antiasthmatic agent adult article asthma clinical article controlled study disease severity drug efficacy female human Iran lung function lung function test male patient care practice guideline spirometry symptom treatment duration treatment response wheezing abnormal respiratory sound aged clinical trial controlled clinical trial drug effect hospitalization inhalational drug administration lung middle aged oral drug administration pathophysiology randomized controlled trial Administration, Inhalation Administration, Oral Adrenal Cortex Hormones Adrenergic beta-Agonists Anti-Asthmatic Agents Humans Practice Guidelines as Topic Respiratory Function Tests Respiratory Sounds Severity of Illness Index
Subjects: WF Respiratory System
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib3 lib3
Date Deposited: 18 May 2020 09:10
Last Modified: 18 May 2020 09:10
URI: http://eprints.mums.ac.ir/id/eprint/16785

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