Impact of Cigarette Smoking on Serum Pro- and Anti-Inflammatory Cytokines and Growth Factors

Daloee, M. H. and Avan, A. and Mirhafez, S. R. and Kavousi, E. and Hasanian-Mehr, M. and Darroudi, S. and Tajfard, M. and Tayefi, M. and Qazizade, H. and Mohammadi, A. and Ferydouni, N. and Ebrahimi, M. and Ghayour-Mobarhan, M. (2017) Impact of Cigarette Smoking on Serum Pro- and Anti-Inflammatory Cytokines and Growth Factors. American Journal of Men's Health, 11 (4). pp. 1169-1173.

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Inflammation plays a key role in the initiation, progression, and clinical manifestation of atherosclerosis. Cigarette smoking is a risk factor for atherosclerosis and cardiovascular disease. The aim of the current study was to investigate the serum concentrations of 12 cytokines and growth factors (EGF, INF-γ, IL-1α/-1β/-2/-4/-6/-8/-10, MCP-1, TNF-α, and VEGF) in an Iranian population, including 192 smokers, comparing these values with concentrations in nonsmokers. One hundred and ninety-two cases were enrolled from the Mashhad University of Medical Sciences. Of these cases, 82 were cigarette smokers and 110 were nonsmokers. Sex and age were matched for the two groups. The serum concentration of 12 cytokines and growth factors were determined using EV-3513-cytokine-biochip arrays, by competitive chemiluminescence immunoassays. The level of serum MCP-1 was significantly (p <.001) lower in the female group of cigarette smokers (mean = 88.1 dL/ng), compared with nonsmokers (mean = 155.6 dL/ng). There were no significant differences for the other cytokines and growth factors between the groups. Our finding demonstrate the association of MCP-1 with cigarette smoking, supporting further studies in larger population on evaluating the role of cigarette smoking on pro-/anti-inflammatory cytokines. © 2015, © The Author(s) 2015.

Item Type: Article
Additional Information: Cited By :8 Export Date: 16 February 2020 Correspondence Address: Ghayour-Mobarhan, M.; Biochemistry of Nutrition Research Center, Mashhad University of Medical ScienceIran; email:
Uncontrolled Keywords: cigarette smoking cytokines growth factors inflammation biological marker cytokine lipid signal peptide blood cross-sectional study female human Iran luminescence male middle aged smoking Biomarkers Cross-Sectional Studies Humans Intercellular Signaling Peptides and Proteins Lipids Luminescent Measurements
Subjects: QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib3 lib3
Date Deposited: 13 May 2020 08:09
Last Modified: 13 May 2020 08:09

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