Association of hematocrit with blood pressure and hypertension

Emamian, M. and Hasanian, S. M. and Tayefi, M. and Bijari, M. and Movahedian far, F. and Shafiee, M. and Avan, A. and Heidari-Bakavoli, A. and Moohebati, M. and Ebrahimi, M. and Darroudi, S. and Zamani, P. and Azarpazhooh, M. R. and Nematy, M. and Safarian, M. and Ferns, G. A. and Esmaeili, H. and Parizadeh, M. R. and Ghayour-Mobarhan, M. (2017) Association of hematocrit with blood pressure and hypertension. Journal of Clinical Laboratory Analysis, 31 (6).

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Background: Hypertension (HTN) is a risk factor for stroke, renal failure, and cardiovascular disease. The association between biochemical and hematological parameters with high blood pressure may provide a more precise approach to risk prediction conferred by HTN in these patients. Objective: The aim of current study was to explore whether biochemical and hematological parameters are associated with HTN in a cohort study with a 7-year follow-up. Materials and Methods: A total of 9808 individuals were enrolled and recruited as part of the Mashhad Stroke and Heart Atherosclerotic Disorders (MASHAD) cohort study, and biochemical and hematological factors were measured in all subjects. Univariate and multivariate logistic regression analysis were performed to determine the association of biochemical and hematological parameters with HTN. Results: Several biochemical parameters including fasting plasma glucose (FBG), serum high-sensitivity C-reactive protein (hs-CRP), triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and uric acid were increased in hypertensive participants. In contrast, serum high-density lipoprotein cholesterol (HDL-C) was lower in hypertensive individuals. Furthermore, we demonstrated that hematological parameters including white blood cell (WBC) count, red blood cell (RBC) count, hemoglobin (HGB), hematocrit (HCT), and mean corpuscular hemoglobin (MCH) were higher in the hypertensive group compared to the control group. But mean corpuscular volume (MCV), and red cell distribution width (RDW), were decreased in the hypertensive group. Furthermore, our results strongly suggested that among these parameters, hematocrit was the independent risk factor for hypertension in the population. Conclusion: We demonstrated the association of altered biochemical and hematological factors with hypertension supporting the value of emerging markers for early prediction of high blood pressure in prone individuals. © 2017 Wiley Periodicals, Inc.

Item Type: Article
Additional Information: Cited By :22 Export Date: 16 February 2020 CODEN: JCANE Correspondence Address: Parizadeh, M.R.; Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical SciencesIran; email:
Uncontrolled Keywords: biochemical risk factors cardiovascular diseases hematological parameters hypertension glucose high density lipoprotein cholesterol low density lipoprotein cholesterol triacylglycerol uric acid biological marker cholesterol adult Article blood pressure measurement body height body mass body weight cardiovascular parameters cholesterol blood level cohort analysis controlled study disease association erythrocyte count female follow up glucose blood level hematocrit hemoglobin blood level human leukocyte count major clinical study male mean corpuscular hemoglobin mean corpuscular volume protein blood level red blood cell distribution width risk assessment risk factor uric acid blood level waist circumference blood blood pressure middle aged pathophysiology physiology Biomarkers Body Mass Index Humans Risk Factors
Subjects: WH Hemic and Lymphatic System
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib3 lib3
Date Deposited: 12 May 2020 08:10
Last Modified: 12 May 2020 08:10

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