The effectiveness of a 5 retinoic acid peel combined with microdermabrasion for facial photoaging: A randomized, double-blind, placebo-controlled clinical trial

Faghihi, G. and Fatemi-Tabaei, S. and Abtahi-Naeini, B. and Siadat, A. H. and Sadeghian, G. and Ali Nilforoushzadeh, M. and Mohamadian-Shoeili, H. (2017) The effectiveness of a 5 retinoic acid peel combined with microdermabrasion for facial photoaging: A randomized, double-blind, placebo-controlled clinical trial. Dermatology Research and Practice, 2017.

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Abstract

Background. Tretinoin has been shown to improve photoaged skin. This study was designed to evaluate the efficacy and tolerability of a 5 retinoic acid peel combined with microdermabrasion for facial photoaging. Materials and Methods. Forty-five patients, aged 35-70, affected by moderate-to-severe photodamage were enrolled in this trial. All patients received 3 sessions of full facial microdermabrasion and 3 sessions of either 5 retinoic acid peel or placebo after the microdermabrasion. Efficacy was measured using the Glogau scale. Patients were assessed at 2 weeks and 1, 2, and 6 months after treatment initiation. Results. The mean ± SD age of participants was 49.55±11.61 years, and the majorities (73.3) were female. Between 1 month and 2 months, participants reported slight but statistically significant improvements for all parameters (P<0.001). In terms of adverse effects, there were statistically significant differences reported between the 5 retinoic acid peel groups and the control group (P<0.001). The majority of adverse effects reported in the study were described as mild and transient. Conclusion. This study demonstrated that 5 retinoic acid peel cream combined with microdermabrasion was safe and effective in the treatment of photoaging in the Iranian population. This trial is registered with IRCT2015121112782N8. © 2017 Gita Faghihi et al.

Item Type: Article
Additional Information: Cited By :1 Export Date: 16 February 2020 Correspondence Address: Fatemi-Tabaei, S.; Skin Diseases and Leishmaniasis Research Center, Department of Dermatology, Isfahan University of Medical SciencesIran; email: fatemisaghi@yahoo.com
Uncontrolled Keywords: corticosteroid retinoic acid adult aged Article burning sensation clinical article controlled study dermatological equipment dermatological procedure disease severity double blind procedure drug efficacy drug safety erythema facial photoaging female glogau scale human male microdermabrasion photoaging randomized controlled trial skin disease skin disease assessment skin edema skin pruritus skin scaling skin ulcer
Subjects: WR Dermatology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib3 lib3
Date Deposited: 23 May 2020 05:24
Last Modified: 23 May 2020 05:24
URI: http://eprints.mums.ac.ir/id/eprint/16812

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