The effect of intravenous dextrose administration for prevention of post-operative nausea and vomiting after laparoscopic cholecystectomy: A double-blind, randomised controlled trial

Firouzian, A. and Kiasari, A. Z. and Godazandeh, G. and Baradari, A. G. and Alipour, A. and Taheri, A. and Zeydi, A. E. and Montazemi, M. (2017) The effect of intravenous dextrose administration for prevention of post-operative nausea and vomiting after laparoscopic cholecystectomy: A double-blind, randomised controlled trial. Indian Journal of Anaesthesia, 61 (10). pp. 803-810.

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Abstract

Background and Aims: Post-operative nausea and vomiting (PONV) is a common and distressing complication after laparoscopic cholecystectomy (LC). The aim of this study was to evaluate the effect of intravenous (IV) dextrose administration for the prophylaxis of PONV after LC. Methods: In a double-blind, randomised controlled trial, a total of 150 female patients who were scheduled for elective LC were randomly assigned into two groups (A and B). Thirty minutes before induction of anaesthesia, patients received an infusion of 500 cc lactated Ringer’s solution (Group A) and 5 dextrose in lactated Ringer’s solution (Group B) and over a period of 30 min. All patients rated their nausea and vomiting intensity using the verbal rating scale immediately at post-anaesthesia care unit (PACU) arrival; 30, 60, 90 and 120 min after arriving at the PACU and 6, 12 and 24 h after surgery. Results: There was a statistically significant time trend and group effect along with significant differences in time/group interaction effect in both groups for nausea and vomiting scores (P < 0.05). A low negative correlation coefficient was found (r = −0.394, P < 0.001) between blood glucose levels and nausea scores upon PACU arrival. Dextrose administration reduced the odds of vomiting events compared to placebo (estimate: −0.87, odds ratio = 0.42, 95 confidence interval: 0.28–0.64). Conclusion: Administration of IV dextrose before anaesthesia induction may be recommended as an effective, and safe method for the prophylaxis of PONV after LC. © 2017 Indian Journal of Anaesthesia.

Item Type: Article
Additional Information: Cited By :4 Export Date: 16 February 2020 Correspondence Address: Montazemi, M.; Department of Anesthesiology, Imam Khomeini Hospital, Amir Mazandarani BoulevardIran; email: maryam.montazami@gmail.com
Uncontrolled Keywords: Cholecystectomy Dextrose Glucose Laparoscopic cholecystectomy Post-operative nausea and vomiting cisatracurium fentanyl midazolam morphine placebo propofol adult Article capnometry controlled study double blind procedure electrocardiography female human major clinical study male point of care system postoperative nausea and vomiting prophylaxis prospective study pulse oximetry randomized controlled trial rating scale
Subjects: WI Digestive System
WK Endocrine System
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib3 lib3
Date Deposited: 04 May 2020 04:31
Last Modified: 04 May 2020 04:31
URI: http://eprints.mums.ac.ir/id/eprint/16819

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