Expression of cell adhesion molecule CD44 in gastric adenocarcinoma and its prognostic importance

Ghaffarzadehgan, K. and Jafarzadeh, M. and Raziee, H. R. and Sima, H. R. and Esmaili-Shandiz, E. and Hosseinnezhad, H. and Taghizadeh-Kermani, A. and Moaven, O. and Bahrani, M. (2008) Expression of cell adhesion molecule CD44 in gastric adenocarcinoma and its prognostic importance. World Journal of Gastroenterology, 14 (41). pp. 6376-6381.

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Aim: To evaluate the relation of cluster of differentiation 44 (CD44) expression with clinicopathological features of gastric adenocarcinoma, and also its effect on prognosis with an emphasis on the differences between intestinal and diffuse types. Methods: From 2000 to 2006, 100 patients with gastric adenocarcinoma, who had undergone total or subtotal gastrectomy without any prior treatment, were studied. Haematoxylin & eosin (HE) staining was used for histological evaluation, including the type (Lauren's classification) and grading of the tumor. The expression of CD44 in the gastric adenocarcinoma mucosa and the adjacent mucosa were determined by immunohistochemistry. The survival analysis was obtained using the Kaplan-Meier test. Results: Of 100 patients, 74 (74) patients were male. The tumors were categorized as intestinal type (78) or diffuse type (22). Sixty-five percent of patients were CD44-positive. CD44 expression was not detected in normal gastric mucosa. Rather, CD44 was more commonly expressed in the intestinal subtype (P = 0.002). A significant relation was seen between the grade of tumor and the expression of CD44 (P = 0.014). The survival analysis showed a poor prognosis of patients with CD44-positive tumors (P = 0.008); and this was more prominent in the intestinal (P = 0.001) rather than diffuse type. Conclusion: Cell adhesion molecule CD44 is highly expressed in gastric adenocarcinoma. CD44 expression is correlated with a poor prognosis in patients with the intestinal type of gastric adenocarcinoma. CD44 can, therefore, be utilized as a prognostic marker for this group of patients. © 2008 The WJG Press. All rights reserved.

Item Type: Article
Additional Information: Cited By :51 Export Date: 16 February 2020 CODEN: WJGAF Correspondence Address: Jafarzadeh, M.; Gastric Cancer Research Group, Mashhad University of Medical Sciences, 51 Jami Street, Mashhad, Iran; email:
Uncontrolled Keywords: Cell adhesion molecules Cluster of differentiation 44 Gastric cancer Immunohistochemistry Survival rate Hermes antigen CD44 protein, human tumor marker adult aged antigen expression article cancer classification cancer grading cancer survival controlled study female histopathology human human tissue major clinical study male partial gastrectomy prognosis stomach adenocarcinoma total stomach resection adenocarcinoma cancer staging cell differentiation gastrectomy immunology Kaplan Meier method middle aged mortality pathology stomach mucosa stomach tumor time treatment outcome Aged, 80 and over Antigens, CD44 Gastric Mucosa Humans Kaplan-Meiers Estimate Neoplasm Staging Stomach Neoplasms Time Factors Tumor Markers, Biological
Subjects: WI Digestive System
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib3 lib3
Date Deposited: 29 Apr 2020 07:37
Last Modified: 29 Apr 2020 07:37

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