Hypericum perforutum and Vitamin B6 as a treatment for premenstrual syndrome

Ghazanfarpour, M. and Abdolahian, S. and Khadivzadeh, T. and Kaviani, M. (2017) Hypericum perforutum and Vitamin B6 as a treatment for premenstrual syndrome. Jundishapur Journal of Natural Pharmaceutical Products, 12 (2).

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Abstract

Background: It is shown that the premenstrual syndrome is related to a plethora of problems due to its direct and indirect effects on work, school, home, and productivity or inefficiency of relationships with others. Methods: A double-blind, randomized controlled clinical trial (RCTs) was conducted in gynecology clinic of Zeinabieh Hospital affiliated to Shiraz University of Medical Sciences. Two hundred and thirty eight patients with premenstrual syndrome participated in the study. The prospective menstrual daily (MD) were filled by patients two months prior to the intervention. Then, they were randomly allocated into three groups: one group received two Hypericum perforutum tablets containing 330 ?ghypericin; the second group received two vitamin B6 tablets containing 40mg of vitamin B6, and the third group took two placebo tablets daily from the first to 30th day of menstrual cycle for two cycles. Results: The mean total score decreased from 34.47 ± 6.82 to 20.68 ± 5.72 (40) in the perforan group, from 33.93 ± 6.95 to 20.92 ± 5.26 (38) in the vitamin B6 and from 33.86±6.16 to 23.90±6 (29) in the control group. The mean total score demonstrated a statistically significant decrease in the three arms compared to the baseline (P < 0.001). Also, the comparison of the three groups showed a significant difference at terminal weeks (P < 0.002). Conclusions: Hypericum perforutum and vitamin B6 are safe, well tolerated and effective drugs to treat females with moderate to severe premenstrual syndrome in Iran. © 2016, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences.

Item Type: Article
Additional Information: Cited By :1 Export Date: 16 February 2020 Correspondence Address: Ghazanfarpour, M.; Fatemeh College of Nursing and Midwifery, Shiraz University of Medical SciencesIran; email: ghazanfarpm901@mums.ac.ir
Uncontrolled Keywords: Hypericum perforutum Premenstrual syndrome Vitamin B6 hypericin placebo pyridoxine adult Article breast tenderness comparative study constipation controlled study diarrhea dizziness double blind procedure drug withdrawal female headache human Hypericum perforatum loss of appetite major clinical study menstrual cycle nausea prospective study randomized controlled trial rash scoring system tablet university hospital xerostomia
Subjects: WP Gynecology
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib3 lib3
Date Deposited: 29 Apr 2020 08:46
Last Modified: 29 Apr 2020 08:46
URI: http://eprints.mums.ac.ir/id/eprint/16832

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