Evaluation of anti-cancer activity of PLGA nanoparticles containing crocetin

Hafezi Ghahestani, Z. and Alebooye Langroodi, F. and Mokhtarzadeh, A. and Ramezani, M. and Hashemi, M. (2017) Evaluation of anti-cancer activity of PLGA nanoparticles containing crocetin. Artificial Cells, Nanomedicine and Biotechnology, 45 (5). pp. 955-960.

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Abstract

Poor solubility of crocetin has limited its use as a potential chemotherapeutic agent. In this study, a crocetin nanocarrier was formulated based on poly(lactic-co-glycolic acid) (PLGA) polymer. The effect of preparation conditions on the size and entrap efficiency of PLGA nanoparticles (NPs) via single emulsion/solvent evaporation method was evaluated. Cytotoxicity of crocetin and crocetin-encapsulated PLGA NPs was assayed in MCF-7 cell line. In PLGA formulations, the optimal condition was found to be 5 polyvinyl alcohol (PVA), crocetin:polymer ratio 1:20 and dichloromethane as organic solvent. Obtained results demonstrated that the encapsulation of crocetin in PLGA significantly increased the cytotoxicity of this compound. © 2016 Informa UK Limited, trading as Taylor & Francis Group.

Item Type: Article
Additional Information: Cited By :11 Export Date: 16 February 2020 Correspondence Address: Hashemi, M.; Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical SciencesIran; email: hashemim@mums.ac.ir
Uncontrolled Keywords: Cancer crocetin encapsulation PLGA saffron Cell culture Dichloromethane Emulsification Nanoparticles Chemotherapeutic agents Poly (vinyl alcohol) (PVA) Poly(lactic-co-glycolic acid) Preparation conditions Diseases nanocarrier polyglactin polyvinyl alcohol antineoplastic agent carotenoid drug carrier lactic acid nanoparticle polyglycolic acid polylactic acid-polyglycolic acid copolymer Article controlled study Crocus sativus cytotoxicity dose response drug release emulsion evaporation flow cytometry IC50 in vitro study MCF-7 cell line nanoencapsulation particle size zeta potential apoptosis chemistry drug effects human Antineoplastic Agents Carotenoids Drug Carriers Drug Liberation Humans MCF-7 Cells
Subjects: QV pharmacology
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib3 lib3
Date Deposited: 29 Apr 2020 06:24
Last Modified: 23 May 2020 04:01
URI: http://eprints.mums.ac.ir/id/eprint/16839

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