Association between VDR gene polymorphisms (rs 1544410, rs 7975232, rs 2228570, rs 731236 and rs 11568820) and susceptibility to breast cancer in a sample of southeastern Iranian population

Hashemi, S. M. and Arbabi, N. and Hashemi, M. and Mashhadi, M. A. and Allahyari, A. and Sadeghi, M. (2017) Association between VDR gene polymorphisms (rs 1544410, rs 7975232, rs 2228570, rs 731236 and rs 11568820) and susceptibility to breast cancer in a sample of southeastern Iranian population. International Journal of Cancer Management, 10 (3).

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Abstract

Background: Vitamin D receptor (VDR) is a key nuclear receptor that is associated with the risk and progression of breast cancer (BC). Objectives: The present study investigated the Fok1, Bsm1, Taq1 and Cdx2 polymorphisms in the VDR gene and susceptibility to BC in a sample of Southeastern Iranian population. Methods: This case-control study was conducted on 180 women with BC and 178 age-matched healthy women. RFLP-PCR method was used for analysis of Bsm1 (rs 1544410), Apa1 (rs 7975232), Fok1 (rs 2228570) and Taq1 (rs 731236) and also TETRA-ARMS method for Cdx2 (rs 11568820). Results: No significant correlation was found between polymorphisms of Taq1, Fok1 and Apa1 with BC, but was for Bsm1 (odds ratio (OR) = 3.452, 95 CI 1.769 - 6.738; P < 0.001). Also, there was a significant correlation between the case and control groups for Cdx2 (OR = 3.720, 95 CI 2.224 - 6.225; P < 0.001) and allele A in Cdx2 had just significant correlation with BC. Conclusions: The present study findings showed that there were significant correlations between Bsm1 and Cdx2 polymorphisms with BC in women of Sistan and Baluchestan Province (southeastern Iran). Also, signals of Rs1544410-Bsm1 and Rs11568820-Cdx2 positions were difference with routes of estrogen and progesterone per person and they probably act independently. © 2017, International Journal of Cancer Management.

Item Type: Article
Additional Information: Cited By :2 Export Date: 16 February 2020 Correspondence Address: Arbabi, N.; Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical SciencesIran; email: narges.arbabi@gmail.com
Uncontrolled Keywords: Breast cancer Polymorphism Southeastern Iran VDR vitamin D receptor adult allele Apa1 gene Article breast carcinogenesis Bsm1 gene cancer patient case control study Cdx2 gene controlled study correlation analysis cross-sectional study DNA polymorphism female Fok1 gene genetic susceptibility genotype HER2 gene human human cell Iranian people major clinical study polymerase chain reaction restriction fragment length polymorphism Taq1 gene VDR gene
Subjects: WP Gynecology
QU Biochemistry
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib3 lib3
Date Deposited: 28 Apr 2020 09:16
Last Modified: 28 Apr 2020 09:16
URI: http://eprints.mums.ac.ir/id/eprint/16849

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