Anticancer and apoptosis-inducing effects of quercetin in vitro and in vivo

Hashemzaei, M. and Far, A. D. and Yari, A. and Heravi, R. E. and Tabrizian, K. and Taghdisi, S. M. and Sadegh, S. E. and Tsarouhas, K. and Kouretas, D. and Tzanakakis, G. and Nikitovic, D. and Anisimov, N. Y. and Spandidos, D. A. and Tsatsakis, A. M. and Rezaee, R. (2017) Anticancer and apoptosis-inducing effects of quercetin in vitro and in vivo. Oncology Reports, 38 (2). pp. 819-828.

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Abstract

The present study focused on the elucidation of the putative anticancer potential of quercetin. The anticancer activity of quercetin at 10, 20, 40, 80 and 120 μM was assessed in vitro by MMT assay in 9 tumor cell lines (colon carcinoma CT-26 cells, prostate adenocarcinoma LNCaP cells, human prostate PC3 cells, pheocromocytoma PC12 cells, estrogen receptor-positive breast cancer MCF-7 cells, acute lymphoblastic leukemia MOLT-4 T-cells, human myeloma U266B1 cells, human lymphoid Raji cells and ovarian cancer CHO cells). Quercetin was found to induce the apoptosis of all the tested cancer cell lines at the utilized concentrations. Moreover, quercetin significantly induced the apoptosis of the CT-26, LNCaP, MOLT-4 and Raji cell lines, as compared to control group (P<0.001), as demonstrated by Annexin V/PI staining. In in vivo experiments, mice bearing MCF-7 and CT-26 tumors exhibited a significant reduction in tumor volume in the quercetin-treated group as compared to the control group (P<0.001). Taken together, quercetin, a naturally occurring compound, exhibits anticancer properties both in vivo and in vitro.

Item Type: Article
Additional Information: Cited By :64 Export Date: 16 February 2020 CODEN: OCRPE Correspondence Address: Rezaee, R.; Clinical Research Unit, Faculty of Medicine, Mashhad University of Medical SciencesIran; email: raminrezaee1983@gmail.com
Uncontrolled Keywords: Annexin V/PI Apoptosis Cancer treatment Cytotoxicity MTT assay Quercetin animal cell animal experiment animal model animal tissue antineoplastic activity Article cancer cell line cell viability controlled study female human human cell in vitro study in vivo study malignant neoplasm mouse nonhuman priority journal tumor volume animal cell proliferation drug effects drug screening genetics MCF-7 cell line neoplasm pathology tumor cell line Animals Cell Line, Tumor Humans MCF-7 Cells Mice Neoplasms Xenograft Model Antitumor Assays
Subjects: QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib3 lib3
Date Deposited: 29 Apr 2020 05:08
Last Modified: 29 Apr 2020 05:08
URI: http://eprints.mums.ac.ir/id/eprint/16853

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