Prognostic significance of Mucinous histologic subtype on oncologic outcomes in patients with colorectal cancer

Hosseini, S. and Bananzadeh, A. M. and Salek, R. and Zare-Bandamiri, M. and Kermani, A. T. and Mohammadianpanah, M. (2017) Prognostic significance of Mucinous histologic subtype on oncologic outcomes in patients with colorectal cancer. Annals of Coloproctology, 33 (2). pp. 57-63.

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Abstract

Purpose: Mucinous adenocarcinomas account for about 10 of all colorectal cancers. This study aimed to investigate the prognostic impact of mucinous histologic subtype on oncologic outcomes in patients with colorectal cancer. Methods: This retrospective study was performed at two large tertiary university hospitals. We analyzed the characteristics, prognostic factors, and survival of patients with colorectal cancer who were treated and followed up between 2000 and 2013. Results: Totally, 144 of 1,268 patients with a colorectal adenocarcinoma (11.4) had mucinous histologic subtype. Statistically significant results found in this research are as follows: Mucinous histologic subtype tended to present in younger patients and to have larger tumor size, higher histologic grade, higher node stage, larger number of positive nodes, and higher rate of perineural invasion compared to nonmucinous histologic subtype. On the univariate analysis, mucinous subtype was a prognostic factor for disease-free and overall survival. On the multivariate analysis, primary tumor location, node stage and lymphatic-vascular invasion were independent prognostic factors for the local control rate. Rectal tumor location, higher disease stage, tumor grade II, and presence of lymphatic-vascular invasion had negative influences on disease-free survival, as did rectal tumor location, higher disease stage and presence of lymphatic-vascular invasion on overall survival. Conclusion: Mucinous histologic subtype was associated with some adverse pathologic features in patients with colorectal cancer; however, it was not an independent prognostic factor for oncologic outcome. © 2017 The Korean Society of Coloproctology.

Item Type: Article
Additional Information: Cited By :6 Export Date: 16 February 2020 Correspondence Address: Mohammadianpanah, M.; Colorectal Research Center, Department of Radiation Oncology, Shiraz University of Medical SciencesIran; email: mohpanah@gmail.com
Uncontrolled Keywords: Colorectal neoplasms Mucinous adenocarcinoma Prognosis Survival rate Treatment outcome capecitabine fluorouracil folinic acid oxaliplatin adjuvant therapy adolescent age aged Article cancer combination chemotherapy cancer prognosis cancer staging cancer survival colloid carcinoma colon carcinogenesis colorectal cancer colorectal carcinoma controlled study disease association disease free survival female follow up histopathology human lymphatic system disease major clinical study male monotherapy neoadjuvant chemotherapy overall survival retrospective study single drug dose tertiary care center tumor invasion tumor localization tumor volume university hospital very elderly
Subjects: WI Digestive System
QT physiology
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib3 lib3
Date Deposited: 28 Apr 2020 08:02
Last Modified: 28 Apr 2020 08:02
URI: http://eprints.mums.ac.ir/id/eprint/16860

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