Bilateral cytomegalovirus retinitis in a healthy infant

Hosseini, S. M. and Moosavi, M. N. and Shoeibi, N. and Sakhaee, M. and Ghavamsaeedi, H. (2017) Bilateral cytomegalovirus retinitis in a healthy infant. Journal of Current Ophthalmology, 29 (1). pp. 66-68.

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Purpose To report a case of bilateral cytomegalovirus (CMV) retinitis in an otherwise healthy infant. Methods A four-month-old, healthy, male infant was evaluated for visual inattention. Results This full-term infant with a normal birth weight and an uneventful gestational period was referred with symptoms of visual inattention, fever, and agitation one week prior to admission. Ocular involvements were detected in the form of bilateral pan uveitis with diffuse bilateral retinitis and vasculitis with hemorrhage in the peripheral retina and posterior pole. CMV DNA was detected in the patient's ocular sample and cerebrospinal fluid by polymerase chain reaction (PCR). He was treated with intravitreal and systemic ganciclovir. Unfortunately, the infant died because of CMV encephalitis. Therefore, bilateral CMV retinitis (CMVR), which was probably transmitted from the mother, was diagnosed in this immunocompetent infant. Conclusions The present case highlights the possibility of CMVR in immunocompetent infant associated with systemic CMV infection, even during the postnatal period. Therefore, a high index of clinical suspicion and prompt treatment may be life-saving in similar cases. © 2016 Iranian Society of Ophthalmology

Item Type: Article
Additional Information: Cited By :2 Export Date: 16 February 2020 Correspondence Address: Hosseini, S.M.; Eye Research Center, Khatam-Al-Anbia Eye Hospital, Abutaleb Junction, Ghareni Blvd., Iran; email:
Uncontrolled Keywords: Cytomegalovirus Ganciclovir Retinitis immunoglobulin G immunoglobulin M agitation Article birth weight blood cell count case report cerebrospinal fluid analysis child death Cytomegalovirus retinitis echography fever gestational age hepatitis B rapid test hepatitis C rapid test Herpes simplex virus HIV test human human tissue immune deficiency infant lymphocyte count male newborn screening ophthalmoscopy polymerase chain reaction retina hemorrhage serology thorax radiography toxoplasmosis uveitis vaginal delivery Varicella zoster virus vasculitis
Subjects: WS Pediatrics
WW Ophthalmology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib3 lib3
Date Deposited: 28 Apr 2020 08:06
Last Modified: 28 Apr 2020 08:06

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