Evaluation of oral mucosa epithelium in type II diabetic patients by an exfoliative cytology method

Jajarm, H. H. and Mohtasham, N. and Rangiani, A. (2008) Evaluation of oral mucosa epithelium in type II diabetic patients by an exfoliative cytology method. Journal of oral science, 50 (3). pp. 335-340.

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Diabetes mellitus is a common metabolic disease that causes chronic hyperglycemia and disturbances in carbohydrate, lipid, and protein metabolism. Although diabetes can cause considerable cellular changes, this field has attracted little research. We therefore decided to evaluate the quantitative and qualitative changes in oral epithelial cells using an exfoliative cytology method. In 30 control individuals and 30 patients with type II diabetes, smears were obtained from two distinct oral sites: the buccal mucosa and tongue dorsum. The oral smears were stained using Papanicolaou solution. Quantitative and qualitative changes were evaluated in each slide. For this purpose, 50 clearly defined cells in each slide were microscopically evaluated, and photographs were subjected to computerized morphometric analysis. Cytoplasmic and nuclear areas in the diabetic group were significantly higher than in the control group. The cytoplasmic/nuclear ratio was lower in the control group. At both smear sites, the proportion of cells with nuclear changes was higher in the diabetic group. Diabetes mellitus can cause alterations in the oral epithelium that are detectable with this exfoliative cytology method. The method may be viable in evaluating this disease.

Item Type: Article
Additional Information: Cited By :22 Export Date: 16 February 2020 Correspondence Address: Jajarm, H.H.
Uncontrolled Keywords: adult aged article case control study cell nucleus cell size cytodiagnosis cytology epithelium cell female human male middle aged mouth mucosa non insulin dependent diabetes mellitus pathology Case-Control Studies Diabetes Mellitus, Type 2 Epithelial Cells Humans
Subjects: WK Endocrine System
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib3 lib3
Date Deposited: 28 Apr 2020 07:31
Last Modified: 28 Apr 2020 07:31
URI: http://eprints.mums.ac.ir/id/eprint/16872

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