The effects of crocin on the symptoms of depression in subjects with metabolic syndrome

Jam, I. N. and Sahebkar, A. H. and Eslami, S. and Mokhber, N. and Nosrati, M. and Khademi, M. and Foroutan-Tanha, M. and Ghayour-Mobarhan, M. and Hadizadeh, F. and Ferns, G. and Abbasi, M. (2017) The effects of crocin on the symptoms of depression in subjects with metabolic syndrome. Advances in Clinical and Experimental Medicine, 26 (6). pp. 925-930.

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Background. Studies have suggested that metabolic syndrome (MetS) is associated with increased depressive symptoms, and reducing depression in subjects with MetS is important. Crocin, an active component of saffron, has useful properties for subjects with MetS, including antidepressant properties. Objectives. The aim of the study was to assess the effect of a preparation of crocin on the symptoms of depression in subjects with MetS, and the relationship between changes in those symptoms and the serum pro-oxidant/anti-oxidant balance (PAB). Material and methods. This sub-study was carried out on 34 subjects with MetS from the authors' previous randomized double-blind controlled clinical trial (RCT), all of whom met the inclusion criteria for this study. The subjects were randomly assigned to treatment and placebo groups (n = 17 in each group) and received each 30 mg of crocin (2 tablets of 15 mg) or placebo for 8 weeks. Depressive symptoms were assessed using the Beck Depression Inventory (BDI). The BDI questionnaire was completed for each subject at the baseline and at the end of the 8th week of treatment. Blood samples were taken from the subjects before and after the intervention period. Statistical analyses were performed using the SPSS for Windows, v. 16 (SPSS Inc., Chicago, USA). Results. Out of the 34 participants enrolled, 33 completed the trial. The degree of depression decreased significantly in the crocin group (p = 0.005), but not in the placebo group (p > 0.05), and the difference between the 2 groups was statistically significant (p = 0.013). No significant relationship was observed between changes in depression symptoms and changes in the serum PAB (p > 0.05). Conclusions. This study demonstrates that at a dose of 30 mg per day for 8 weeks, crocin reduced the symptoms of depression in subjects with MetS compared to the control group, and this effect was independent of its effect on the serum PAB. © 2017 by Wroclaw Medical University.

Item Type: Article
Additional Information: Cited By :14 Export Date: 16 February 2020 Correspondence Address: Ghayour-Mobarhan, M.; Metabolic Research Center, School of Medicine, Mashhad University of Medical SciencesIran; email:
Uncontrolled Keywords: Crocin Depression Metabolic syndrome Saffron antioxidant oxidizing agent placebo antidepressant agent biological marker carotenoid adult Article Beck Depression Inventory clinical article controlled study double blind procedure drug effect female human male metabolic syndrome X randomized controlled trial software statistical analysis treatment outcome affect blood complication drug effects Iran middle aged psychology questionnaire time factor Antidepressive Agents Biomarkers Carotenoids Double-Blind Method Humans Surveys and Questionnaires Time Factors
Subjects: WB Practice of Medicine
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib3 lib3
Date Deposited: 23 May 2020 06:30
Last Modified: 23 May 2020 06:30

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