Minimally invasive radioguided parathyroid surgery using low-dose Tc-99m-MIBI - Comparison with standard high dose

Jangjoo, A. and Sadeghi, R. and Mousavi, Z. and Mohebbi, M. and Khaje, M. and Asadi, M. (2017) Minimally invasive radioguided parathyroid surgery using low-dose Tc-99m-MIBI - Comparison with standard high dose. Endokrynologia Polska, 68 (4). pp. 398-401.

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Abstract

Introduction: Surgery remains the most effective treatment for primary hyperparathyroidism (PHPT). Minimally invasive radioguided parathyroidectomy (MIRP) is a common technique for detecting and excising abnormal parathyroid glands. The aim of this study was to compare injections of low-dose and high-dose (99m) Tc methoxy isobutyl isonitrile (MIBI) for intraoperative localisation of parathyroid adenomas by means of a gamma probe in patients with primary hyperparathyroidism (PHPT). Material and methods: Thirty patients with PHPT and a preoperative diagnosis of parathyroid adenoma were enrolled between 2010 and 2012. They were considered as Group B and underwent MIRP using 5 mCi Tc-99m MIBI, and their perioperative data were compared with twenty patients treated with conventional 20 mCi Tc-99m MIBI previously (Group A). Results: Group A was made up of 20 patients (mean age, 41.55 years; 14 women and 6 men), and group B included 30 patients (mean age, 40.43 years; 19 women and 11 men). The mean serum parathyroid hormone (PTH) and calcium values were recorded pre-and postoperatively. The mean follow-up period for the patients in the two groups was 18.4 and 16.5 months, respectively. Pre-operative evaluation demonstrated that the groups were statistically similar. Intraoperative data and success rate of surgery showed no difference between the two groups. No significant complication was detected after surgeries and no recurrence happened in either of the two groups during the follow-up period. Conclusions: A new protocol of MIRP using low doses of Tc-99m-MIBI resulted in an excellent success rate. Comparing results of the study, we conclude that low-dose Tc-99m-MIBI may be preferred for identification of parathyroid adenomas intraoperatively by means of a gamma probe in PHPT patients because it appears to be as effective as high-dose Tc-99m-MIBI. (Endokrynol Pol 2017; 68 (4): 398-401).

Item Type: Article
Additional Information: Cited By :1 Export Date: 16 February 2020 CODEN: EDPKA Correspondence Address: Asadi, M.; Surgical Oncology Research Centre, School of Medicine, Mashhad University of Medical SciencesIran; email: asadimdr@yahoo.com
Uncontrolled Keywords: Primary hyperparathyroidism Radiation exposure Radioguided parathyroidectomy calcium methoxy isobutyl isonitrile technetium tc 99m adenoma adult blood comparative study complication diagnostic imaging female human male middle aged parathyroid gland parathyroid tumor parathyroidectomy perioperative period procedures treatment outcome Humans Hyperparathyroidism, Primary Parathyroid Glands Parathyroid Neoplasms Technetium Tc 99m Sestamibi
Subjects: WK Endocrine System
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib3 lib3
Date Deposited: 03 Mar 2020 09:49
Last Modified: 03 Mar 2020 09:49
URI: http://eprints.mums.ac.ir/id/eprint/16876

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