Efficacy of combined albendazol and praziquntel and their loaded solid lipid nanoparticles components in chemoprophylaxis of experimental hydatidosis

Jelowdar, A. and Rafiei, A. and Abbaspour, M. R. and Rashidi, I. and Rahdar, M. (2017) Efficacy of combined albendazol and praziquntel and their loaded solid lipid nanoparticles components in chemoprophylaxis of experimental hydatidosis. Asian Pacific Journal of Tropical Biomedicine, 7 (6). pp. 549-554.

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Abstract

Objective To evaluate the efficacy of combined ABZ and PZQ and their solid lipid nanoparticles in chemoprophylaxis of cystic echinococcosis (CE). Methods ABZ and PZQ loaded solid lipid nanoparticles (SLNs) were prepared by high shear homogenization and microemulsion congealing techniques with some minor modification. Nanoparticles average size, polydispersity index (PDI), and particle size distribution were determined by scanning electron microscopy (SEM) and photon correlation spectroscopy. Forty females BALB/c were experimentally infected by protoscoleces (PSC) and randomly divided into four equal groups of 10 mice. After the end of the 3 months treatment period and 2 months rest, mice were sacrificed and the peritoneal cavity was opened for removal, counting, measuring, and histological analysis of hydatid cyst. Results The results indicated that ABZ and PZQ chemoprophylaxis treatment reduced the wet weight and size of developed cysts 77.3 and 79, respectively. The corresponding result for the ABZ and PZQ loaded SLNs was 83 and 85, respectively. Conclusions This study for the first time demonstrated that ABZ and PZQ loaded SLNs is superior to free ABZ and PZQ for the chemoprophylaxis of CE in mice. © 2017 Hainan Medical University

Item Type: Article
Additional Information: Cited By :9 Export Date: 16 February 2020 Correspondence Address: Rafiei, A.; Health Research Institute, Infectious and Tropical Diseases Research Center, Faculty of Medicine, Ahvaz Jundishapur University of Medical SciencesIran; email: rafieiabdollah@yahoo.com
Uncontrolled Keywords: Albendazole Echinococcosis High pressure homogenization Praziquantel Solid lipid nanoparticles (SLNs) solid lipid nanoparticle animal experiment animal model animal tissue Article chemoprophylaxis controlled study dispersity drug efficacy encapsulation female microemulsion mouse nonhuman particle size priority journal scanning electron microscopy
Subjects: QV pharmacology
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib3 lib3
Date Deposited: 03 Mar 2020 09:45
Last Modified: 03 Mar 2020 09:45
URI: http://eprints.mums.ac.ir/id/eprint/16878

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