Co-administration of walnut (Juglans Regia) prevents systemic hypertension induced by long-term use of dexamethasone: A promising strategy for steroid consumers

Joukar, S. and Ebrahimi, S. and Khazaei, M. and Bashiri, A. and Shakibi, M. R. and Naderi, V. and Shahouzehi, B. and Alasvand, M. (2017) Co-administration of walnut (Juglans Regia) prevents systemic hypertension induced by long-term use of dexamethasone: A promising strategy for steroid consumers. Pharmaceutical Biology, 55 (1). pp. 184-189.

[img] Text
Co administration of walnut Juglans regia prevents systemic hypertension induced by long term use of dexamethasone a promising strategy for steroid.pdf

Download (1MB)

Abstract

Context: The long-term consumption of glucocorticoids (GCs) may induce serious adverse effects such as hypertension. There is sufficient evidence related to the benefit of walnuts on the cardiovascular system. Objective: This study assesses the effect of methanol extract of walnut Juglans regia L. (Juglandaceae) on dexamethasone-induced hypertension and the possible mechanisms in Wistar rats. Material and methods: Animals were randomized into control, kernel extract (100 and 200 mg/kg/d, orally), dexamethasone (0.03 mg/kg/d, subcutaneously), dexamethasone + kernel (100 and 200 mg/kg/d, separately), and dexamethasone + captopril (25 mg/kg/d, orally) groups. Animals were treated with water, kernel extract or captopril by gavage 4 d before and during 11 d of saline or dexamethasone treatment. On the 16th day, blood pressure (BP) was recorded and blood samples were collected to measure nitric oxide (NO). Animal hearts were frozen for measurement of malondialdehyde (MDA) and glutathione peroxidase (GPX). Results: Dexamethasone increased the diastolic BP and MDA/GPX ratio in comparison with control group (128 ± 7 vs. 105 ± 3 mmHg, p < 0.05 and 0.2 ± 0.046 vs. 0.08 ± 0.02, p < 0.05). Combination of dexamethasone and walnut (200 mg/kg) prevented the dexamethasone-induced diastolic hypertension (109 ± 3 vs. 128 ± 7 mmHg; p < 0.05), increased the GPX level (14.8 ± 1.46 vs. 5.1 ± 0.64 unit/mg, p < 0.05), reduced the MDA/GPX ratio (0.16 ± 0.015 vs. 0.2 ± 0.046) and improved serum NO level. Conclusion: Similar to captopril, walnut extract normalized dexamethasone-induced hypertension. A part of this beneficial effect apparently involves maintaining balance of the redox system and NO production. © 2016 The Author(s).

Item Type: Article
Additional Information: Cited By :3 Export Date: 16 February 2020 CODEN: PHBIF Correspondence Address: Joukar, S.; Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical SciencesIran; email: jokar@kmu.ac.ir
Uncontrolled Keywords: Glucocorticoid Kernel Redox system captopril dexamethasone glutathione peroxidase Juglans regia extract malonaldehyde methanol nitric oxide plant extract sodium chloride unclassified drug antihypertensive agent antioxidant animal experiment animal tissue Article blood pressure measurement blood sampling controlled study diastolic blood pressure drug effect drug mechanism feeding hypertension Juglans regia long term care male nonhuman protein blood level rat animal blood blood pressure cardiac muscle chemically induced chemistry disease model drug effects heart rate isolation and purification medicinal plant metabolism nut oxidation reduction reaction pathophysiology phytotherapy time factor walnut Wistar rat Animals Antihypertensive Agents Antioxidants Disease Models, Animal Juglans Malondialdehyde Myocardium Nuts Oxidation-Reduction Plant Extracts Plants, Medicinal Rats, Wistar Time Factors
Subjects: WD Nutrition Disease and metabolic diseases
WG Cardiovascular System
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib3 lib3
Date Deposited: 03 Mar 2020 09:43
Last Modified: 03 Mar 2020 09:43
URI: http://eprints.mums.ac.ir/id/eprint/16879

Actions (login required)

View Item View Item