Efficacy and safety of povidone-iodine pleurodesis in malignant pleural effusions

Kahrom, H. and Aghajanzadeh, M. and Asgari, M. and Kahrom, M. (2017) Efficacy and safety of povidone-iodine pleurodesis in malignant pleural effusions. Indian Journal of Palliative Care, 23 (1). pp. 53-56.

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Introduction: Malignant pleural effusion (MPE) is determined by the detection of malignant cells in pleural fluid or pleural tissue. Neoplasm of lung, breast, ovary and lymphoma are the causes of more than 75 of MPE. Pleurodesis is a usual technique in the management of MPE to achieve a symphysis between two layers of the pleura, and various chemical agents have been used in an attempt to produce pleurodesis. With regard to complications and limitations of these sclerosing agents, efficacy and safety of povidone-iodine have been investigated in this study. Materials and Methods: Between June 2014 and June 2016, 63 consecutive patients were admitted to the Department of Thoracic Surgery because of symptomatic MPE. After insertion of a chest tube, pleurodesis with instillation of povidone-iodine was performed. Thyroid and renal function tests were checked, and success rate as well as recurrence of MPE was monitored in the next follow-up visits. Results: The complete response to this procedure was about 53.57, and failure of treatment was 10.71 with efficacy of 82.2. The most common complication was pain during instillation (26.9). Changes in thyroid and renal function tests were not significant. Conclusion: Povidone-iodine is a safe and effective agent with minor side effects in pleurodesis of patients with MPEs and can be used as an accessible and low-cost alternative than other sclerosing agents. © 2017 Indian Journal of Palliative Care | Published by Wolters Kluwer-Medknow.

Item Type: Article
Additional Information: Cited By :4 Export Date: 16 February 2020 Correspondence Address: Kahrom, M.; Department of Cardiovascular Surgery, Ghaem Hospital, Mashhad University of Medical SciencesIran; email: kahrommh@mums.ac.ir
Uncontrolled Keywords: Malignant pleural effusion pleurodesis povidone-iodine
Subjects: QV pharmacology
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib3 lib3
Date Deposited: 27 Apr 2020 07:07
Last Modified: 27 Apr 2020 07:07
URI: http://eprints.mums.ac.ir/id/eprint/16881

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