Evaluation of the anticonvulsant activities of rosa damascena on the PTZ induced seizures in wistar rats

Kheirabadi, M. and Moghimi, A. and Rakhshande, H. and Rassouli, M. B. (2008) Evaluation of the anticonvulsant activities of rosa damascena on the PTZ induced seizures in wistar rats. Journal of Biological Sciences, 8 (2). pp. 426-430.

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The goal of the present study was to evaluate the anticonvulsant property of Rosa damascena essence as a natural origin compound on the PTZ induced seizures in rats. To produce animal models with different graded of seizures (partial to generalized tonic-clonic seizures), PTZ was injected in 40 male Wistar rats. Prior to PTZ injections, the experimental groups of rats were received 500, 750 and 1000 mg kg-1 body weight essential oil. During the experimental period the epileptiform behaviors of all rats of different groups, was evaluated before and after essential injections. The results showed that the Rosa essential can attenuate the latent periods of the beginning of convulsions as well as the severity of seizures in a dose dependent manner. The flavonoids of Rosa damascena may act via GABAA receptors as pervious studies have proposed for flavonoids of other medicinal plants. © 2008 Asian Network for Scientific Information.

Item Type: Article
Additional Information: Cited By :20 Export Date: 16 February 2020 Correspondence Address: Kheirabadi, M.; Department of Biology, Faculty of Sciences, Ferdowsi University of Mashhad, P.O. Box 91775-1436, Mashhad, Iran
Uncontrolled Keywords: Essential PTZ pentylen tetrazol Rosa damascena Seizure 4 aminobutyric acid A receptor essential oil flavonoid pentetrazole plant extract Rosa damascena extract unclassified drug animal experiment animal model anticonvulsant activity article controlled study disease severity dose response drug efficacy drug mechanism focal epilepsy grand mal seizure male nonhuman rat rose tonic clonic seizure Animalia Rattus Rattus norvegicus Rosa x damascena
Subjects: WL Nervous system
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib3 lib3
Date Deposited: 03 Mar 2020 10:55
Last Modified: 03 Mar 2020 10:55
URI: http://eprints.mums.ac.ir/id/eprint/16890

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