Zinc supplementation in adult mechanically ventilated trauma patients is associated with decreased occurrence of ventilator-associated pneumonia: A secondary analysis of a prospective, observational study

Kiabi, F. H. and Alipour, A. and Darvishi-Khezri, H. and Aliasgharian, A. and Zeydi, A. E. (2017) Zinc supplementation in adult mechanically ventilated trauma patients is associated with decreased occurrence of ventilator-associated pneumonia: A secondary analysis of a prospective, observational study. Indian Journal of Critical Care Medicine, 21 (1). pp. 34-39.

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Abstract

Background: Ventilator-associated pneumonia (VAP) is a type of lung infection that typically affects critically ill patients undergoing mechanical ventilation (MV) in the Intensive Care Unit (ICU). The aim of this analysis is to determine potential association between zinc supplementation with the occurrence of VAP in adult mechanically ventilated trauma patients. Subjects and Methods: This secondary analysis of a prospective observational study was carried out over a period of 1 year in ICUs of one teaching hospital in Iran. A total of 186 adults mechanically ventilated trauma patients, who required at least 48 h of MV and received zinc sulfate supplement (n = 82) or not (n = 104) during their ICU stay, were monitored for the occurrence of VAP until their discharge from the ICU or death. Results: Forty-one of 186 patients developed VAP, 29.09 days after admission (95 confidence interval CI: 26.27-31.9). The overall incidence of VAP was 18.82 cases per 1000 days of intubation (95% CI: 13.86-25.57). Patients who received zinc sulfate supplement have smaller hazard of progression to VAP than others (hazard ratio: 0.318 95% CI: 0.138-0.732; P < 0.0001). Conclusion: The findings show that zinc supplementation may be associated with a significant reduction in the occurrence of VAP in adult mechanically ventilated trauma patients. Further well-designed randomized clinical trials to confirm the efficacy of this potential preventive modality are warranted. © 2017 Indian Journal of Critical Care Medicine.

Item Type: Article
Additional Information: Cited By :1 Export Date: 16 February 2020 Correspondence Address: Aliasgharian, A.; Thalassemia Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical SciencesIran; email: amieei@yahoo.com
Uncontrolled Keywords: Intensive Care Units supplementation ventilator-associated pneumonia zinc sulfate adult aged Article controlled study critically ill patient disease association female follow up hospitalization human incidence intensive care unit intubation Iran major clinical study male mortality rate obesity observational study prospective study secondary analysis teaching hospital ventilated patient ventilator associated pneumonia
Subjects: WF Respiratory System
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib3 lib3
Date Deposited: 03 Mar 2020 10:57
Last Modified: 03 Mar 2020 10:57
URI: http://eprints.mums.ac.ir/id/eprint/16899

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