Effective Medicinal Plant in Cancer Treatment, Part 2: Review Study

Kooti, W. and Servatyari, K. and Behzadifar, M. and Asadi-Samani, M. and Sadeghi, F. and Nouri, B. and Zare Marzouni, H. (2017) Effective Medicinal Plant in Cancer Treatment, Part 2: Review Study. Journal of Evidence-Based Complementary and Alternative Medicine, 22 (4). pp. 982-995.

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Cancer is the second cause of death after cardiovascular diseases. With due attention to rapid progress in the phytochemical study of plants, they are becoming popular because of their anticancer effects. The aim of this study was to investigate the effective medicinal plants in the treatment of cancer and study their mechanism of action. In order to gather information the keywords “traditional medicine,” “plant compounds,” “medicinal plant,” “medicinal herb,” “toxicity,” “anticancer effect,” “cell line,” and “treatment” were searched in international databases such as ScienceDirect, PubMed, and Scopus and national databases such as Magiran, Sid, and Iranmedex, and a total of 228 articles were collected. In this phase, 49 nonrelevant articles were excluded. Enhancement P53 protein expression, reducing the expression of proteins P27, P21, NFκB expression and induction of apoptosis, inhibition of the PI3K/Akt pathway, and reduction of the level of acid phosphatase and lipid peroxidation are the most effective mechanisms of herbal plants that can inhibit cell cycle and proliferation. Common treatments such as radiotherapy and chemotherapy can cause some complications. According to results of this study, herbal extracts have antioxidant compounds that can induce apoptosis and inhibit cell proliferation by the investigated mechanisms. © 2017, © The Author(s) 2017.

Item Type: Article
Additional Information: Cited By :23 Export Date: 16 February 2020 Correspondence Address: Zare Marzouni, H.; Immunology Research Center, Mashhad University of Medical SciencesIran; email: zaremh931@gmail.com
Uncontrolled Keywords: cell line medicinal herbs plant compounds toxicity
Subjects: QV pharmacology
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib3 lib3
Date Deposited: 03 Mar 2020 10:50
Last Modified: 03 Mar 2020 10:50
URI: http://eprints.mums.ac.ir/id/eprint/16903

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