Determination of interleukin-6 and tumor necrosis factor-alpha concentrations in Iranian-Khorasanian patients with preeclampsia

Afshari, J. T. and Ghomian, N. and Shameli, A. and Shakeri, M. T. and Fahmidehkar, M. A. and Mahajer, F. and Khoshnavaz, R. and Emadzadeh, M. (2005) Determination of interleukin-6 and tumor necrosis factor-alpha concentrations in Iranian-Khorasanian patients with preeclampsia. BMC Pregnancy and Childbirth, 5.

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Abstract

Background: Our objective was to determine the role of Interleukin-6 (IL-6) and Tumor Necrosis Factor-alpha (TNF- alpha), markers of immune activation and endothelial dysfunction, in patients with preeclampsia. Methods: Twenty four women with preeclampsia and eighteen antepartum normotensive pregnant women were recruited as controls. Serum levels of IL-6 and TNF-alpha. were measured by enzyme-linked immunosorbent assay. We used independent-samples t test to assess the differences in the concentration of cytokines in preeclamptic patients and control subjects. Results: IL-6 levels mean (S.D.) were significantly higher in preeclamptic women 5.8 (4.85) pg/ml compared to normal pregnant women 3.01 (2.45) pg/ml (p=0.02). There was no significant change in concentration of TNF-alpha in preeclamptic women 53.8 (30.0) pg/ml compared to normal pregnant women 51.9 (33.8) pg/ml (p>0.1). Conclusions: The results of this study show that IL-6 as a pro-inflammatory cytokine is present in higher concentration in women with preeclampsia. The study was undertaken in women with established preeclampsia and it is not possible to determine whether the increased concentration of IL-6 is a cause or consequence of the disease. Furthermore, these findings suggest that serum TNF-alpha level is not associated with preeclampsia. © 2005 Tavakkol Afshari et al., licensee BioMed Central Ltd.

Item Type: Article
Additional Information: Cited By :37 Export Date: 16 February 2020 CODEN: BPCMB Correspondence Address: Afshari, J.T.; Immunogenetics Department, Immunology Research Group, Bu-Ali Research Institute, Bu-Ali Sq., Mashhad, Iran; email: jtavakkol@yahoo.com
Uncontrolled Keywords: interleukin 6 tumor necrosis factor alpha article clinical article controlled study enzyme linked immunosorbent assay female human immune response Iran pathogenesis preeclampsia protein blood level protein determination statistical analysis
Subjects: WP Gynecology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 23 Apr 2020 08:40
Last Modified: 23 Apr 2020 08:40
URI: http://eprints.mums.ac.ir/id/eprint/16914

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