Prognostic factors for esophageal squamous cell Carcinoma-A Population-Based study in Golestan province, Iran, a high incidence area

Aghcheli, K. and Marjani, H. A. and Nasrollahzadeh, D. and Islami, F. and Shakeri, R. and Sotoudeh, M. and Abedi-Ardekani, B. and Ghavamnasiri, M. R. and Razaei, E. and Khalilipour, E. and Mohtashami, S. and Makhdoomi, Y. and Rajabzadeh, R. and Merat, S. and Sotoudehmanesh, R. and Semnani, S. and Malekzadeh, R. (2011) Prognostic factors for esophageal squamous cell Carcinoma-A Population-Based study in Golestan province, Iran, a high incidence area. PLoS ONE, 6 (7).

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Abstract

Golestan Province in northern Iran is an area with a high incidence of esophageal squamous cell carcinoma (ESCC). We aimed to investigate prognostic factors for ESCC and survival of cases in Golestan, on which little data were available. We followed-up 426 ESCC cases participating in a population-based case-control study. Data were analyzed using the Kaplan-Meier method and the Cox proportional hazard models. Median survival was 7 months. Age at diagnosis was inversely associated with survival, but the association was disappeared with adjustment for treatment. Residing in urban areas (hazard ratio, HR = 0.70; 95 CI 0.54-0.90) and being of non-Turkmen ethnic groups (HR = 0.76; 95 CI 0.61-0.96) were associated with better prognosis. In contrast to other types of tobacco use, nass (a smokeless tobacco product) chewing was associated with a slightly poorer prognosis even in models adjusted for other factors including stage of disease and treatment (HR = 1.38; 95 CI 0.99-1.92). Opium use was associated with poorer prognosis in crude analyses but not in adjusted models. Almost all of potentially curative treatments were associated with longer survival. Prognosis of ESCC in Golestan is very poor. Easier access to treatment facilities may improve the prognosis of ESCC in Golestan. The observed association between nass chewing and poorer prognosis needs further investigations; this association may suggest a possible role for ingestion of nass constituents in prognosis of ESCC. © 2011 Aghcheli et al.

Item Type: Article
Additional Information: Cited By :39 Export Date: 16 February 2020 Correspondence Address: Malekzadeh, R.; Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran; email: malek@ams.ac.ir
Uncontrolled Keywords: opiate adult age aged article cancer chemotherapy cancer incidence cancer staging cancer survival esophageal squamous cell carcinoma ethnic group female health care access human Iran major clinical study male population research prognosis smoking survival rate survival time urban area confidence interval demography esophagus tumor incidence middle aged proportional hazards model squamous cell carcinoma survival Nicotiana tabacum Carcinoma, Squamous Cell Confidence Intervals Esophageal Neoplasms Humans Proportional Hazards Models Survival Analysis
Subjects: WI Digestive System
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 02 May 2020 09:20
Last Modified: 02 May 2020 09:20
URI: http://eprints.mums.ac.ir/id/eprint/16916

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